L5006
亮氨酸氨基肽酶，微粒体 来源于猪肾脏
Type IV-S, ammonium sulfate suspension, 10-40 units/mg protein (Bradford)
别名:
亮氨肽酶, 亮酰胺氨肽酶, 氨基肽酶 M, 氨肽酶M, 氨肽酶N, 组织蛋白酶 III
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-942-5
MDL number:
Specific activity:
10-40 units/mg protein (Bradford)
产品名称
亮氨酸氨基肽酶，微粒体 来源于猪肾脏, Type IV-S, ammonium sulfate suspension, 10-40 units/mg protein (Bradford)
type
Type IV-S
form
ammonium sulfate suspension
specific activity
10-40 units/mg protein (Bradford)
storage temp.
2-8°C
Quality Level
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Other Notes
一个单位在37°C 下 pH 7.2 时每分钟将水解 1.0μ摩尔 L-亮氨酸-对硝基苯胺为 L -亮氨酸和对硝基苯胺（25°C 下可获得活性约为37°C 下的 40%）。以 L-亮氨酸对硝基苯胺为底物得到的活性是以 L-亮氨酸酰胺为底物得到的活性的 2-5 倍。
Physical form
3.5M (NH4)2SO4 溶液中的悬浮液，pH 7.7，含 10mM MgCl2
Application
猪肾来源微粒体亮氨酸氨肽酶用于从啮齿动物脑-C5 中分离脑啡肽酶（NEP），用于肽消化。
Biochem/physiol Actions
亮氨酸氨肽酶底物特异性广。能水解肽直至产生脯氨酸残基，不会对脯氨酸继续降解。
General description
亮氨酸氨肽酶属于金属蛋白酶家族。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity
Grembecka J, et al.
Journal of medicinal chemistry, 46(13), 2641-2655 (2003)
Rossella Galati et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 58(7-8), 558-561 (2003-08-27)
The ability of synthetic protein fragments to survive the degradative action of aminopeptidases and serum proteolytic enzymes can be remarkably enhanced by slight modifications at their N-terminal alpha-amino group. This can be achieved by addition of beta-alanine or amino acids
Intestinal digestive resistance of immunodominant gliadin peptides
Hausch F, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 283(4), G996-G1003 (2002)
J W Wright et al.
Hypertension (Dallas, Tex. : 1979), 13(6 Pt 2), 910-915 (1989-06-01)
Leucine aminopeptidase M significantly reduced blood pressure for up to 40 minutes when infused intracerebroventricularly into anesthetized spontaneously hypertensive rats (SHR) from a mean +/- SEM of 190 +/- 4 to 94 +/- 7 mm Hg and also in normotensive
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain
Takaki Y, et al.
The Journal of Biological Chemistry, 128(6), 897-902 (2000)
商品
Instructions for working with enzymes supplied as ammonium sulfate suspensions
以硫酸铵悬浮液形式提供的酶的使用指南
相关内容
QC Methods
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