L5169
Anti-LXRβ (C-terminal) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-Ubiquitously expressed nuclear receptor, Anti-LXRB, Anti-Liver X receptor b, Anti-NER, Anti-NER-I, Anti-NR1H2, Anti-Nuclear receptor subfamily 1, group H, member 2, Anti-RIP15, Anti-UNR
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~45 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
western blot: 1:1000-1:2000 using COS7 cells expressing human LXRb
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... NR1H2(7376)
General description
Liver X receptor β (LXRβ) is ubiquitously expressed in the body. The LXRβ gene is mapped to human chromosome 19q13.33. It belongs to the ligand-activated transcription factor family.
Application
Anti-LXRβ (C-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Anti-LXRβ(C-terminal) specifically recognizes human LXRβ.
Liver X receptor β (LXRβ) is involved in cholesterol metabolism and lipoprotein remodeling. It is essential for the immune system and the central nervous system (CNS). Genetic knockout of either LXRα or LXRβ in transgenic mice results in increased amyloid plaque load. Deletion of LXRβ is implicated in anxiety, neurodegeneration in substantia nigra. It also results in impaired cerebral cortex lamination and behavior response
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
LXRs: The Key Regulators of Intermediary Metabolism in Metabolic Syndrome
Mehrad-Majd H, et al.
Reviews in Clinical Medicine, 4(4) (2017)
Nicholas F Fitz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(20), 6862-6872 (2010-05-21)
High-fat diet and certain dietary patterns are associated with higher incidence of sporadic Alzheimer's disease (AD) and cognitive decline. However, no specific therapy has been suggested to ameliorate the negative effects of high fat/high cholesterol levels on cognition and amyloid
Chiara Gabbi et al.
Molecular endocrinology (Baltimore, Md.), 23(2), 129-136 (2008-12-17)
Liver X receptors, LXRalpha and LXRbeta, are nuclear receptors belonging to the large family of transcription factors. After activation by oxysterols, LXRs play a central role in the control of lipid and carbohydrate metabolism as well as inflammation. The role
Yu-Jiao Li et al.
Journal of neuroinflammation, 16(1), 132-132 (2019-07-01)
Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the brain. Here, the modes of action of LXRs and the epigenetic mechanisms regulating LXRβ expression in anterior cingulate
Xiaotang Fan et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(36), 13445-13450 (2008-09-05)
Liver X receptor (LXR) beta regulates cholesterol levels in the brain and is essential for maintenance of motor neurons in the spinal cord and dopaminergic neurons in the substantia nigra. Here, we have examined the expression pattern of LXRbeta protein
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