L5538
Leu-Ser-Lys-Leu-NH2
≥95% (HPLC), suitable for mass spectrometry
别名:
LSKL-NH2
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关于此项目
经验公式（希尔记法）:
C21H42N6O5
分子量:
458.60
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Leu-Ser-Lys-Leu-NH2, ≥95% (HPLC)
InChI
1S/C21H42N6O5/c1-12(2)9-14(23)19(30)27-17(11-28)21(32)25-15(7-5-6-8-22)20(31)26-16(18(24)29)10-13(3)4/h12-17,28H,5-11,22-23H2,1-4H3,(H2,24,29)(H,25,32)(H,26,31)(H,27,30)/t14-,15-,16-,17-/m0/s1
SMILES string
CC(C)C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(N)=O
InChI key
YOKXDNNIFSAXBY-QAETUUGQSA-N
assay
≥95% (HPLC)
form
powder
technique(s)
mass spectrometry (MS): suitable
color
white
storage temp.
−20°C
Biochem/physiol Actions
Leu-Ser-Lys-Leu-NH2 (LSKL-NH2) is found at the C-terminal of the neurotoxic wasp venom α-pompilidotoxin (α-PMTX). A similar peptide Leu-Ser-Lys-Leu (LSKL) is a used to study the activation of TGF-β1 via thrombospondin.
Used to study the activation of TGF-β1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
K Konno et al.
Biochemical and biophysical research communications, 250(3), 612-616 (1998-10-24)
Novel peptide neurotoxins, alpha- and beta-pompilidotoxins (alpha- and beta-PMTXs), were purified from the venoms of the solitary wasps Anoplius samariensis and Batozonellus maculifrons. Their structures were analyzed mostly by MALDI-TOF-MS, which were corroborated by solid-phase synthesis. alpha-PMTX, with 13 amino
P2Y4/TSP-1/TGF-β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.
Yurong Zhang et al.
Brain research bulletin, 149, 106-119 (2019-04-22)
Epilepsy is accompanied by angiogenesis and blood-brain barrier (BBB) disruption. The transforming growth factor-β1 (TGF-β1)/phosphorylated small mothers against decapentaplegic 2 and 3 (pSmad2/3)/vascular endothelial growth factor (VEGF) pathway, activated by thrombospondin-1 (TSP-1), which is further regulated by Y type P2
Xi-sheng Xie et al.
Archives of pharmacal research, 33(2), 275-284 (2010-03-03)
The effects of LSKL, the peptide antagonist of thrombospondin-1 (TSP-1), on renal interstitial fibrosis in rats subjected to unilateral ureteral obstruction (UUO) were investigated. Rats were divided randomly into three groups (n = 20 each): UUO group, sham-operation group and
Emanuele Schiavon et al.
The FEBS journal, 277(4), 918-930 (2010-01-12)
Pompilidotoxins (PMTXs, alpha and beta) are small peptides consisting of 13 amino acids purified from the venom of the solitary wasps Anoplius samariensis (alpha-PMTX) and Batozonellus maculifrons (beta-PMTX). They are known to facilitate synaptic transmission in the lobster neuromuscular junction
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