生物来源
Salmonella enterica (Serotype minnesota Re 595 mutant)
质量水平
表单
lyophilized powder
杂质
<3% Protein (Lowry)
颜色
white to yellow cast
溶解性
water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow
运输
ambient
储存温度
2-8°C
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一般描述
本品由沙门氏菌菌种明尼苏达粒径Re 595（Re突变体）采用酚-氯仿-石油醚提取程序制备而成。来源菌株为 ATCC 49284。菌株 Re 595 的 LPS 中的一种独特结构显示可诱导人血小板分泌和聚集。
应用
- 电荷和聚集模式决定了塑化素与模拟革兰氏阴性菌外膜外叶的LPS单层的相互作用：该研究探讨了电荷和聚集模式如何影响塑化素与来自肠道沙门氏菌血清型Minnesota Re 595等粗糙菌株的脂多糖（LPS）相互作用。这些发现有助于理解微生物耐药机制中涉及的分子相互作用（Michel et al., 2015）。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中，其暴露于细胞表面。它们有助于外膜的完整性，并可保护细胞免受胆汁盐和亲脂性抗生素的作用。
制备说明
通过苯酚-氯仿-石油醚萃取进行制备。
本品可溶于水（5 mg/ml）或细胞培养基（1 mg/ml），产生混浊的淡黄色溶液。溶于生理盐水并涡旋和加热至70-80 oC后，可形成浓度更高但仍然混浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。溶于水和磷酸盐缓冲盐水时，可观察到浑浊的溶液。使用有机溶剂不能形成更清晰的溶液。使用甲醇可产生具有漂浮物的混浊悬浮液，而溶于水会产生均匀的混浊溶液。
本品可溶于水（5 mg/ml）或细胞培养基（1 mg/ml），产生混浊的淡黄色溶液。溶于生理盐水并涡旋和加热至70-80 oC后，可形成浓度更高但仍然混浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。溶于水和磷酸盐缓冲盐水时，可观察到浑浊的溶液。使用有机溶剂不能形成更清晰的溶液。使用甲醇可产生具有漂浮物的混浊悬浮液，而溶于水会产生均匀的混浊溶液。
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide.
Ronan Kapetanovic et al.
BMC genomics, 14, 581-581 (2013-08-30)
The draft genome of the domestic pig (Sus scrofa) has recently been published permitting refined analysis of the transcriptome. Pig breeds have been reported to differ in their resistance to infectious disease. In this study we examine whether there are
Tom C Freeman et al.
BMC biology, 10, 90-90 (2012-11-17)
This work describes the first genome-wide analysis of the transcriptional landscape of the pig. A new porcine Affymetrix expression array was designed in order to provide comprehensive coverage of the known pig transcriptome. The new array was used to generate
S Kumar et al.
Parasite immunology, 34(7), 372-382 (2012-04-11)
Studies have shown that glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum activate macrophages mainly through Toll-like receptor 2 (TLR2)-mediated signalling and to certain extent through TLR4-mediated signalling to induce proinflammatory cytokine production. However, the ability of parasite GPIs to activate dendritic cells
Xianzhu Wu et al.
Journal of immunology (Baltimore, Md. : 1950), 184(8), 4338-4348 (2010-03-17)
Dendritic cells (DCs) play a crucial role in the development of protective immunity to malaria. However, it remains unclear how malaria parasites trigger immune responses in DCs. In this study, we purified merozoites, food vacuoles, and parasite membrane fragments released
Ahsan F Malik et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(50), 20095-20100 (2011-11-24)
Implantation of biomaterials and devices into soft tissues leads to the development of the foreign body response (FBR), which can interfere with implant function and eventually lead to failure. The FBR consists of overlapping acute and persistent inflammatory phases coupled
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
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