biological source
human
recombinant
expressed in E. coli
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.05-0.2 μg/mL ED50 (for chemotaxis of BaF/3 hCXR1 cells), 6-12 μg/mL ED50 (for chemotaxis of IL-2 cultured lymphocytes)
mol wt
predicted mol wt 10.4 kDa
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... XCL1(6375)
Biochem/physiol Actions
Lymphotactin (Lptn), a member of the C or γ subfamily of chemokines, is similar to members of the CC and CXC chemokine families, but lacks two of the four cysteine residues. Recombinant mouse lymphotactin has chemotactic activity for lymphocytes, NK cells, and mouse splenocytes, but not for monocytes or neutrophils.
Member of the C or γ subfamily of chemokines, is similar to members of the CC and CXC chemokine families, but lacks two of the four cysteine residues.
Physical form
Lyophilized from a 0.2 μm filtered solution 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hXCR1.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Lymphotactin: a new class of chemokine.
J A Hedrick et al.
Methods in enzymology, 287, 206-215 (1997-01-01)
Christina Guzzo et al.
PLoS pathogens, 9(12), e1003852-e1003852 (2014-01-05)
CD8+ T cells play a key role in the in vivo control of HIV-1 replication via their cytolytic activity as well as their ability to secrete non-lytic soluble suppressive factors. Although the chemokines that naturally bind CCR5 (CCL3/MIP-1α, CCL4/MIP- 1β
Annabell Bachem et al.
The Journal of experimental medicine, 207(6), 1273-1281 (2010-05-19)
In recent years, human dendritic cells (DCs) could be subdivided into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets. To date, the low frequency of these DCs in human blood
G S Kelner et al.
Science (New York, N.Y.), 266(5189), 1395-1399 (1994-11-25)
In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both
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