Anti-Matrix Metalloproteinase-12, C-Terminal antibody produced in rabbit

Reacts with reduced MMP-12. The C-terminal recognizes most active forms of MMP-12. The hemopexin domain is cleaved in the final form of MMP-12 and the antibody does not detect this final form. The zymogen is approximately 54 kDa and is quickly activated to the 45 kDa form which breaks down to a cascade of active forms, ending with a 22 kDa form.

synthetic peptide corresponding to the C-terminal of human matrix metalloproteinase-12 (macrophage elastase).

Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide

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