Anti-MOG (C-terminal) antibody produced in rabbit

Myelin/oligodendrocyte glycoprotein (MOG) is an integral membrane glycoprotein belonging to the large immunoglobulin superfamily. It is a 26-28kDa glycoprotein localized on chromosome 6p21.3. It consists of an extracellular immunoglobulin-like domain and two hydrophobic regions. It is expressed on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system.

synthetic peptide corresponding to amino acids 231-247 located near the C-terminus of human MOGα1 isoform, conjugated to KLH. This sequence is identical in human MOGα4 and MOGβ1 isoforms, partially found (six amino acids at the C-terminus) in human MOGα2 and MOGα3 isoform, and identical in rat, mouse, and bovine MOG.

Anti-MOG (C-terminal) antibody produced in rabbit is suitable for western blot at a concentration of 2.5-5 ?g/mL using rat brain homogenate (S1 fraction) and rat spinal cord homogenate (P2 fraction).

Myelin/oligodendrocyte glycoprotein (MOG) is a major component of the central nervous system. It is involved in several cellular processes including cellular adhesion, in the regulation of oligodendrocyte microtubule stability and facilitates the interactions between myelin and the immune system. It has been reported that MOG may be involved in the completion and/or maintenance of the myelin sheath, and in cell-cell communication. It has also been observed that mutation or polymorphisms in MOG gene could cause multiple sclerosis.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。