Anti-Maspin antibody produced in rabbit

Maspin gene is located on chromosome 18q21.3 in a cluster of genes encoding members of the ovalbumin family of serine protease inhibitors. Expression of maspin was found also in human cornea in the epithelium, endothelium and stroma cells.

synthetic peptide corresponding to amino acids 333-348 of human maspin with a C-terminal added cysteine, conjugated to KLH.

Anti-Maspin antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

Maspin is a serine protease inhibitor (serpin) with tumor suppressive activities. Maspin protein was identified in a search for tumor suppressor genes that are defective in human breast carcinoma cells. Maspin is expressed in normal mammary epithelial cell strains, but not in most mammary tumor cell lines. Re-expression of maspin in mammary carcinoma cells does not alter the growth properties of the cells in vitro, but reduces their ability to induce tumors, to metastasize in nude mice, and to invade a basement membrane matrix in vitro. The molecular mechanism of maspin action is not clear. Using a two-hybrid system, it has been found that heat shock protein 90, glutathione S-transferase (GST), and heat shock protein 70 interacted with maspin with the highest frequencies. This protein exerts its tumor suppressive role, at least in part, by blocking the activity of pericellular uPA (urokinase Plasminogen Activator).

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide and 1% inactivated bovine serum albumin.

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