Mass Spectrometry in Drug Discovery

This reference summarizes the theory, instrumentation, and application of mass spectrometry and atmospheric pressure ionization to screen, evaluate, and improve the performance and quality of drug candidates. It covers: recent advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing; cassette dosing; the utilization of liquid chromatography/mass spectrometry (LC/MS) in chemical library characterization, combinatorial chemistry, drug transport, and in vivo microdialysis; reliable methods of sample preparation and handling; novel strategies to determine and characterize metabolite structures; the impact of absorption, distribution, metabolism, and elimination properties on drug discovery.