M118
(−)-Methoxyverapamil hydrochloride
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关于此项目
经验公式（希尔记法）:
C28H40N2O5 · HCl
化学文摘社编号:
分子量:
521.09
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Cl[H].COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC
optical activity
[α]26/D −11.7°, c = 5.04 in ethanol(lit.)
solubility
H2O: soluble
Biochem/physiol Actions
Ca2+ channel (L-type) antagonist; active enantiomer of methoxyverapamil.
Disclaimer
Photosensitive
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J A Wagner et al.
Journal of cardiovascular pharmacology, 10 Suppl 10, S1-S9 (1987-01-01)
We studied voltage-sensitive and Na-dependent Ca2+ flux into synaptosomes as well as Na-dependent influx in cardiac sarcolemmal vesicles. Rapid, voltage-sensitive 45Ca2+ influx into synaptosomes is blocked by cadmium (IC50 1 microM) and the novel peptide toxin omega-conotoxin GVIA (30% of
Drug action and cellular calcium regulation.
Janis, P.R., et al. et al.
Advances in Drug Research, 16, 309-309 (1987)
G B Frank
The Journal of pharmacology and experimental therapeutics, 236(2), 505-511 (1986-02-01)
Contractures of the toe muscles of frogs produced by 123 mM K+ were reduced or blocked by verapamil (or D-600) when applied in concentrations of 10(-7) M or more. In concentrations between 10(-7) and 3 X 10(-5) M or less
Maria Trott et al.
PloS one, 9(5), e97478-e97478 (2014-05-16)
HIV neutralizing antibodies (nAbs) represent an important tool in view of prophylactic and therapeutic applications for HIV-1 infection. Patients chronically infected by HIV-1 represent a valuable source for nAbs. HIV controllers, including long-term non-progressors (LTNP) and elite controllers (EC), represent
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