M121
(-)-MDO-NPA 盐酸盐
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关于此项目
经验公式（希尔记法）:
C20H21NO2 · xHCl
化学文摘社编号:
分子量:
307.39 (free base basis)
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
mp
250-252 °C
SMILES字符串
Cl.CCCN1CCc2cccc-3c2[C@H]1Cc4ccc5OCOc5c-34
InChI
1S/C20H21NO2.ClH/c1-2-9-21-10-8-13-4-3-5-15-18(13)16(21)11-14-6-7-17-20(19(14)15)23-12-22-17;/h3-7,16H,2,8-12H2,1H3;1H/t16-;/m1./s1
InChI key
QRTFNNCNSYALRJ-PKLMIRHRSA-N
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
(-)-10,11-Methylenedioxy-N-propylnoraporphine, an orally effective dopamine agonist and duodenal antiulcerogen in the rat.
J L Neumeyer et al.
European journal of pharmacology, 88(2-3), 273-274 (1983-03-25)
A Campbell et al.
Brain research, 403(2), 393-397 (1987-02-17)
The 10-11-methylenedioxy (MDO) derivative of S(+)N-n-propylnorapomorphine (NPA) was prepared and tested as a possible active prodrug to S(+)NPA, which we have recently found to exert in vivo activity suggestive of selective antagonism of dopamine receptors in the limbic forebrain but
P Lampen et al.
Journal of chromatography, 426(2), 283-294 (1988-04-29)
The dopamine receptor agonist R(-)N-n-propylnorapomorphine (NPA) and its proposed pro-drug R(-)10,11-methylenedioxy-N-n-propylnoraporphine (MDO-NPA) were isolated simultaneously from monkey plasma using a solid-phase extraction procedure. R(-)Apomorphine (APO) and R(-)10,11-methylenedioxyaporphine (MDO-APO) were added as internal standards, and separation and quantification were by high-performance
A Campbell et al.
Neuropharmacology, 21(10), 953-961 (1982-10-01)
Substituted and unsubstituted 10,11-methylenedioxy derivatives of apomorphine (APO) or its N-propyl congener (NPA) were synthesized and evaluated for their ability to alter motor activity or to induce stereotyped behavior in the rat. Of these, (-)10,11-methylenedioxy-N-n-propylnoraporphine hydrochloride (MDO-NPA) was the most
G Sperk et al.
Neuropharmacology, 21(12), 1311-1316 (1982-12-01)
High performance liquid chromatography with electrochemical detection was used to assay N-n-propylnorapomorphine (NPA) and other aporphines. Pretreatment of rats with (-)10,11-methylenedioxy-N-n-propylnoraporphine (MDO-NPA) yielded dose-dependent increases in tissue levels of NPA after oral or parenteral administration. Cerebral levels of NPA significantly
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