storage temp.
−20°C
InChI
1S/C11H14N4O4/c1-5-7-10(13-3-12-5)15(4-14-7)11-9(18)8(17)6(2-16)19-11/h3-4,6,8-9,11,16-18H,2H2,1H3
InChI key
FIGBCBGMUIGJBD-UHFFFAOYSA-N
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M D Thompson et al.
Journal of medicinal chemistry, 40(5), 766-770 (1997-02-28)
A series of 2,4,6-trisubstituted-5-nitropyrimidines have been prepared and evaluated for inhibition of proliferation of L1210 and H.Ep.2 cells in vitro. The most potent compound was 6-(dibromomethyl)-2-methoxy-4-morpholino-5-nitropyrimidine (11) (L1210, IC50 = 0.32 microM; H.Ep.2, IC50 = 1.6 microM). Of the 6-substituents
Adenosine phosphorylase-mediated nucleoside toxicity. Application towards the detection of mycoplasmal infection in mammalian cell cultures.
G J McGarrity et al.
Experimental cell research, 139(1), 199-205 (1982-05-01)
B W Hughes et al.
Cancer research, 55(15), 3339-3345 (1995-08-01)
We used a gene transfer-based system to generate highly toxic purine bases in tumor cells transfected with the Escherichia coli purine nucleoside phosphorylase (PNP) gene. Because these toxic purines are membrane permeant, they mediate effective killing of neighboring cells that