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Merck
CN

M1380

N6-单丁酰腺苷3′:5′-环单磷酸盐 钠盐

别名:

6MB-cAMP

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关于此项目

经验公式（希尔记法）:
C14H17N5NaO7P
化学文摘社编号:
70253-67-7
分子量:
421.28
NACRES:
NA.51
PubChem Substance ID:
24896638
UNSPSC Code:
41106305
MDL number:
MFCD00057135
Assay:
≥97.5% (HPLC)
Biological source:
synthetic (organic)
Form:
powder or crystals
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C

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biological source

synthetic (organic)

assay

≥97.5% (HPLC)

form

powder or crystals

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na].CCCC(=O)Nc1ncnc2n(cnc12)C3OC4COP(O)(=O)OC4C3O

InChI

1S/C14H18N5O7P.Na.H/c1-2-3-8(20)18-12-9-13(16-5-15-12)19(6-17-9)14-10(21)11-7(25-14)4-24-27(22,23)26-11;;/h5-7,10-11,14,21H,2-4H2,1H3,(H,22,23)(H,15,16,18,20);;

InChI key

RHNOUOJKQVKESB-UHFFFAOYSA-N

Application

N6-单丁基腺苷3′:5′-环单磷酸钠盐适用于
  • 验证其刺激节后反应长效增强作用的假说
  • 作为蛋白激酶A激活剂，在人原代培养的甲状腺细胞中分析cAMP级联调控基因表达的调节
  • 分析其对假孕兔黄体孕酮产生的影响

Biochem/physiol Actions

激活蛋白激酶A的cAMP的膜透性类似物，对磷酸二酯酶降解耐受

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCC4307
BCBZ9631
BCBZ1718
BCBX4993
BCBW5347

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Ketty Bacallao et al.
PloS one, 8(12), e82354-e82354 (2013-12-19)
In Schwann cells (SCs), cyclic adenosine monophosphate (cAMP) not only induces differentiation into a myelinating SC-related phenotype, but also synergistically enhances the mitogenic action of growth factors such as neuregulin. To better understand the molecular mechanism by which cAMP exerts
Estrogen Uncouples Steroidogenesis from 3?, 5?-Cyclic Adenosine Monophosphate Regulation in the Rabbit Corpus Luteum
Townson DH, et al.
Biology of Reproduction, 53(3), 718-723 (1995)
T Nesbitt et al.
Endocrinology, 124(3), 1184-1189 (1989-03-01)
Previously we have established that abnormal regulation of renal 25-hydroxyvitamin D (25OHD)-1 alpha-hydroxylase in Hyp mice involves the PTH-adenylate cyclase component of enzyme activation. However, it remains unknown if the muted effects of PTH result from 1) abnormal second messenger
Long-term regulation of synaptic acetylcholine release and nicotinic transmission: the role of cyclic AMP
Briggs CA, et al.
British Journal of Pharmacology, 93(2), 399-411 (1988)
T T Puck et al.
Somatic cell and molecular genetics, 17(5), 489-503 (1991-09-01)
Genome exposure studies were carried out on malignant CHO-K1 and C6 rat glioma cells and their respective, phenotypically normal counterparts (reverse-transformed CHO-K1, and both reverse-transformed C6 glioma and normal rat fibroblasts). Cells were subjected to the nick-translation technique previously developed
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全球贸易项目编号

货号GTIN
M1380-100MG04061833007624
M1380-25MG04061833007631

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