M1388
Meclocycline sulfosalicylate salt
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关于此项目
经验公式（希尔记法）:
C22H21ClN2O8 · C7H6O6S
化学文摘社编号:
分子量:
695.05
EC 号:
MDL编号:
UNSPSC代码:
51284010
PubChem化学物质编号:
NACRES:
NA.85
颜色
yellow-green powder
溶解性
methanol: 10 mL, clear, very dark yellow (200 mg + 10 mL MeOH)
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
protein synthesis | interferes
SMILES字符串
OC(=O)c1cc(ccc1O)S(O)(=O)=O.CN(C)[C@H]2[C@@H]3[C@@H](O)C4C(=C)c5c(Cl)ccc(O)c5C(=O)C4=C(O)[C@]3(O)C(=O)C(C(N)=O)=C2O
InChI
1S/C22H21ClN2O8.C7H6O6S/c1-6-9-7(23)4-5-8(26)11(9)16(27)12-10(6)17(28)14-15(25(2)3)18(29)13(21(24)32)20(31)22(14,33)19(12)30;8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h4-5,10,14-15,17,26,28-30,33H,1H2,2-3H3,(H2,24,32);1-3,8H,(H,9,10)(H,11,12,13)/t10?,14-,15+,17+,22+;/m1./s1
InChI key
FYSVKUUNXYGFLA-FRGFDCQGSA-N
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一般描述
Chemical structure: tetracycline
应用
Meclocycline is a tetracycline antibiotic. It is used topically for skin infections. It is used to study papulopustular acne and to study the effectiveness of oral versus topical administration.
生化/生理作用
Meclocycline sulfosalicylate prevents bacterial protein synthesis through 30S ribosome-mediated chain elongation and blocks amino-acyl tRNA A-site binding.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
J V Hirschmann
Archives of dermatology, 124(11), 1691-1700 (1988-11-01)
Topical antibiotics are safe and effective in certain conditions, primarily acne, rosacea, and nasal carriage of Staphylococcus aureus. They are useful in impetigo only when it is of limited extent. Their efficacy in other pyodermas is unclear, although mupirocin is
R S Stern et al.
Archives of dermatology, 120(12), 1571-1578 (1984-12-01)
We used cost-effectiveness analysis to compare the costs, risks, and benefits of two strategies for clearing papulopustular acne; topical therapy alone as initial therapy or a combination of systemic antibiotics and topical agents used at the first visit. Patients treated
The use of antibiotics in acne therapy: oral or topical administration?
E A Eady et al.
The Journal of antimicrobial chemotherapy, 10(2), 89-115 (1982-08-01)
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