M1388
Meclocycline sulfosalicylate salt
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关于此项目
经验公式（希尔记法）:
C22H21ClN2O8 · C7H6O6S
化学文摘社编号:
分子量:
695.05
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284010
EC Number:
277-614-2
MDL number:
InChI key
FYSVKUUNXYGFLA-FRGFDCQGSA-N
InChI
1S/C22H21ClN2O8.C7H6O6S/c1-6-9-7(23)4-5-8(26)11(9)16(27)12-10(6)17(28)14-15(25(2)3)18(29)13(21(24)32)20(31)22(14,33)19(12)30;8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h4-5,10,14-15,17,26,28-30,33H,1H2,2-3H3,(H2,24,32);1-3,8H,(H,9,10)(H,11,12,13)/t10?,14-,15+,17+,22+;/m1./s1
SMILES string
OC(=O)c1cc(ccc1O)S(O)(=O)=O.CN(C)[C@H]2[C@@H]3[C@@H](O)C4C(=C)c5c(Cl)ccc(O)c5C(=O)C4=C(O)[C@]3(O)C(=O)C(C(N)=O)=C2O
color
yellow-green powder
solubility
methanol: 10 mL, clear, very dark yellow (200 mg + 10 mL MeOH)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
General description
Chemical structure: tetracycline
Application
Meclocycline is a tetracycline antibiotic. It is used topically for skin infections. It is used to study papulopustular acne and to study the effectiveness of oral versus topical administration.
Biochem/physiol Actions
Meclocycline sulfosalicylate prevents bacterial protein synthesis through 30S ribosome-mediated chain elongation and blocks amino-acyl tRNA A-site binding.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
R S Stern et al.
Archives of dermatology, 120(12), 1571-1578 (1984-12-01)
We used cost-effectiveness analysis to compare the costs, risks, and benefits of two strategies for clearing papulopustular acne; topical therapy alone as initial therapy or a combination of systemic antibiotics and topical agents used at the first visit. Patients treated
The use of antibiotics in acne therapy: oral or topical administration?
E A Eady et al.
The Journal of antimicrobial chemotherapy, 10(2), 89-115 (1982-08-01)
J V Hirschmann
Archives of dermatology, 124(11), 1691-1700 (1988-11-01)
Topical antibiotics are safe and effective in certain conditions, primarily acne, rosacea, and nasal carriage of Staphylococcus aureus. They are useful in impetigo only when it is of limited extent. Their efficacy in other pyodermas is unclear, although mupirocin is
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