M1544
Resorufin methyl ether
别名:
7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O7-Methylresorufin
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关于此项目
经验公式（希尔记法）:
C13H9NO3
化学文摘社编号:
分子量:
227.22
UNSPSC Code:
12161501
NACRES:
NA.47
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
209529
InChI
1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3
SMILES string
COc1ccc2N=C3C=CC(=O)C=C3Oc2c1
InChI key
KNYYMGDYROYBRE-UHFFFAOYSA-N
assay
≥98.0% (HPLC)
form
powder
mp
≥220 °C (lit.)
solubility
dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange
storage temp.
2-8°C
Quality Level
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Application
Resorufin methyl ether have been used as substrate in the incubation mixture, during the determination of cytochrome P4501A activities such as ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase(MROD) in liver microsomes, using high performance liquid chromatography(HPLC).
Biochem/physiol Actions
Fluorimetric substrate for cytochrome P450 linked enzymes.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1.
McCart C and ffrench-Constant R H
Pest Management Science, 64(6), 639-645 (2008)
Caroline McCart et al.
Pest management science, 64(6), 639-645 (2008-03-14)
The cytochrome P450 gene Cyp6g1 is overtranscribed in all field isolates of DDT-resistant Drosophila melanogaster (Meigen) and confers a fitness advantage when inherited via the female. Overtranscription is associated with the insertion of an Accord transposable element into the 5'
Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection
Hanioka N, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 744(2), 399-406 (2000)
Nicholas E Hadjokas et al.
British journal of pharmacology, 136(3), 347-352 (2002-05-25)
1. Cytochrome P4501A2 (CYP1A2) activates a large number of procarcinogens to carcinogens. Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity. Molecular
Xiaowei Zhang et al.
Toxicology and applied pharmacology, 234(3), 306-313 (2008-12-02)
As part of an ongoing effort to understand aryl hydrocarbon receptor (AhR) mediated toxicity in mink, cDNAs encoding for CYP1A1 and the CYP1A2 mixed function monooxygenases were cloned and characterized. In addition, the effects of selected dibenzofurans on the expression
商品
Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.
一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。
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