Merck
CN

M1547

Sigma-Aldrich

甲硝唑

BioXtra

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别名:
2-甲基-5-硝基咪唑-1-乙醇
经验公式(希尔记法):
C6H9N3O3
CAS号:
分子量:
171.15
Beilstein:
611683
EC 号:
MDL编号:
PubChem化学物质编号:

产品线

BioXtra

杂质

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

灼烧残渣

≤0.1%

颜色

white to light yellow

mp

159-161 °C (lit.)

溶解性

acetic acid: 0.1 M, clear, colorless to yellow

痕量阴离子

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

痕量阳离子

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
Na: ≤0.01%
Pb: ≤0.001%
Zn: ≤0.0005%

抗生素抗菌谱

Gram-negative bacteria
parasites

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES string

CC1=NC=C([N+]([O-])=O)N1CCO

InChI

1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

InChI key

VAOCPAMSLUNLGC-UHFFFAOYSA-N

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一般描述

化学结构:咪唑

应用

甲硝唑是一种硝基咪唑,用于治疗阿米巴病、阴道炎、毛滴虫感染、贾第鞭毛虫病、厌氧菌和密螺旋体感染。甲硝哒唑用于研究脱氧核糖核酸的损伤和修复,已经发现在猪痢疾短螺旋体中诱导基因转移剂VSH-1。它通常用于治疗牙周炎,还用于生物利用度研究。

生化/生理作用

甲硝哒唑是一种前药,对厌氧菌具有选择性,因为它们能够在细胞内将甲硝哒唑还原为活性形式。还原甲硝唑与脱氧核糖核酸共价结合,破坏其螺旋结构,诱导脱氧核糖核酸链断裂并抑制细菌核酸合成。最终导致细菌细胞死亡。

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说明
价格

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Carc. 1B - Muta. 1B - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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