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M1559

Moxonidine hydrochloride

≥98%

别名:

4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride, BDF-5895

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关于此项目

经验公式（希尔记法）:
C9H12ClN5O · HCl
化学文摘社编号:
75438-58-3
分子量:
278.14
NACRES:
NA.77
PubChem Substance ID:
24278537
UNSPSC Code:
12352200
MDL number:
MFCD06795643
Assay:
≥98%
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Quality Segment

assay

≥98%

originator

Solvay

SMILES string

Cl.COc1nc(C)nc(Cl)c1NC2=NCCN2

InChI

1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H

InChI key

ZZPAWQYZQVUVHX-UHFFFAOYSA-N

Gene Information

Application

Moxonidine hydrochloride has been used:
  • as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method
  • as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC)
  • as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN)

Biochem/physiol Actions

Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.

Features and Benefits

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Solvay. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

PPE（个人防护设备）

Eyeshields, Gloves, type N95 (US)

象形图

Skull and crossbones
GHS06

警示词

Danger

危险代码

H301,H336

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

靶器官

Central nervous system

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

闪点 (F)

No data available

闪点 (°C)

No data available

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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