M184
3-吗啉吡啶亚胺 盐酸盐
solid
别名:
3-（4-吗啉基）丁香酮亚胺 盐酸盐, SIN-1 盐酸盐, 林西多明 盐酸盐
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关于此项目
经验公式（希尔记法）:
C6H10N4O2 · HCl
化学文摘社编号:
分子量:
206.63
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
form
solid
color
off-white
solubility
H2O: >10 mg/mL
storage temp.
−20°C
SMILES string
Cl[H].[NH-]c1c[n+](no1)N2CCOCC2
InChI
1S/C6H10N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5,7H,1-4H2;1H
InChI key
NCGICGYLBXGBGN-UHFFFAOYSA-N
Biochem/physiol Actions
在溶液中自发释放一氧化氮 (NO)，激活鸟苷酸环化酶并引起循环 GMP 增加。本品为血管扩张剂，可抑制血小板聚集。它利用分子氧产生超氧阴离子和一氧化氮，自发形成过氧亚硝基阴离子。
溶解时自发释放一氧化氮 (NO)，激活鸟苷酸环化酶，引起环鸟苷酸增多；血管扩张剂。
Disclaimer
Hygroscopic, photosensitive
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
K I Thelen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 345(1), 93-99 (1992-01-01)
The modulating effects of exogenous and endogenous nitric oxide (NO) on the cardiac anaphylactic reaction and eicosanoid release were investigated in isolated perfused sensitized guinea-pig hearts using 3-morpholinosydnonimine (SIN-1), the active metabolite of molsidomine, as NO-donor and NG-nitro-L-arginine (NNA) as
K A Jones et al.
The American journal of physiology, 266(1 Pt 1), L9-16 (1994-01-01)
Nitrovasodilators relax airway smooth muscle by both guanosine 3',5'-cyclic monophosphate (cGMP)-dependent and cGMP-independent mechanisms and by mechanisms that reduce cytosolic calcium concentration ([Ca2+]i). This study was conducted to determine the relative importance of these mechanisms in relaxation of canine tracheal
P Arvola et al.
European journal of pharmacology, 214(2-3), 289-292 (1992-04-22)
The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and
Tangying Lu et al.
The Journal of clinical investigation, 121(10), 4015-4029 (2011-09-14)
Cancer immunotherapeutic approaches induce tumor-specific immune responses, in particular CTL responses, in many patients treated. However, such approaches are clinically beneficial to only a few patients. We set out to investigate one possible explanation for the failure of CTLs to
Wei Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(9), 2439-2444 (2011-07-12)
Peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via its cytotoxic effects, this study was undertaken to investigate whether the neuroprotective effect of myricetin is associated with inhibition of peroxynitrite-mediated DNA damage, a critical
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