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Merck
CN

M1927

Sigma-Aldrich

Matrix Metalloproteinase-2 from human fibroblasts

>95% (SDS-PAGE), buffered aqueous glycerol solution

别名:

72 Kd Gelatinase, 72 Kd Type IV collagenase, Gelatinase A, MMP-2

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MDL编号:
UNSPSC代码:
12352200
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方案

>95% (SDS-PAGE)

表单

buffered aqueous glycerol solution

分子量

72 kDa

UniProt登记号

运输

dry ice

储存温度

−70°C

基因信息

human ... MMP2(4313)

生化/生理作用

Degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Specifically cleaves type IV collagen, a major structural component of basement membranes.

外形

Solution in 10 mM sodium phosphate, pH 7.4, 250 mM sodium chloride, 2% DMSO, and 50% (v/v) glycerol.

分析说明

The enzyme is free of its endogenous inhibitor, TIMP-2 and other matrix metalloproteinases.

法规信息

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Beiqin Yu et al.
BMC cell biology, 14, 17-17 (2013-03-21)
Fibroblasts play a critical role in tumorigenesis, tumor progression and metastasis. However, their detailed molecular characteristics and clinical significance are still elusive. TAGLN is an actin-binding protein that plays an important role in tumorigenesis. We investigated the interaction between cancer
Minggang Wei et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(1), 65-69 (2013-04-20)
The accumulation of extracellular matrix (ECM) is one of the main causes of renal fibrosis. Emerging evidence suggests that the metabolic enzyme of ECM is associated with renal fibrosis. In this study, we applied randomly controlled trial to check the
J C Irwin et al.
The Journal of clinical investigation, 97(2), 438-447 (1996-01-15)
Proteinases are likely effectors of endometrial menstrual breakdown. We have investigated proteinase production by human endometrial stromal cells subjected in vitro to progesterone (P) withdrawal, the physiologic stimulus for menstruation. Culture media of cells exposed to estradiol, P, or estradiol
P C Brooks et al.
Cell, 92(3), 391-400 (1998-02-26)
Angiogenesis depends on both cell adhesion and proteolytic mechanisms. In fact, matrix metalloproteinase 2 (MMP-2) and integrin alphavbeta3 are functionally associated on the surface of angiogenic blood vessels. A fragment of MMP-2, which comprises the C-terminal hemopexin-like domain, termed PEX
Ulrike Hampel et al.
Endocrinology, 154(6), 2034-2045 (2013-03-30)
Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular

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