M226
p-MPPF dihydrochloride
solid
别名:
4-Fluoro-N-(2-[4-(2-methoxyphenyl)1-piperazinyl]ethyl)-N-(2-pyridinyl)benzamide dihydrochloride
表单
solid
颜色
white
溶解性
ethanol: 15 mg/mL
H2O: 19 mg/mL
储存温度
2-8°C
SMILES字符串
Cl[H].Cl[H].COc1ccccc1N2CCN(CC2)CCN(C(=O)c3ccc(F)cc3)c4ccccn4
InChI
1S/C25H27FN4O2.2ClH/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20;;/h2-13H,14-19H2,1H3;2*1H
InChI key
TZOICBMBENXHNK-UHFFFAOYSA-N
基因信息
human ... HTR1A(3350)
生化/生理作用
Selective 5-HT1A serotonin receptor antagonist. More potent than p-MPPI.
法律信息
Manufactured and sold under license from the University of Pennsylvania, U.S. Patent 5,744,121.
免责声明
吸湿
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
R J Thielen et al.
The Journal of pharmacology and experimental therapeutics, 277(2), 661-670 (1996-05-01)
p-MPPI [4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido] ethylpiperazine] and p-MPPF [4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine] competitively antagonized 5-HT1A receptor activation in the rat, as measured by hypothermia, forepaw treading and 5-HT turnover; they exhibited to partial agonist activity on any of these measures. When given i.p., p-MPPI and
Effects of novel 5-HT1A receptor antagonists on measures of post-synaptic 5-HT1A receptor activation in vivo.
Thielen, R.J. et al.
Life Sciences, 56 (1995)
H F Kung et al.
Synapse (New York, N.Y.), 23(4), 344-346 (1996-08-01)
A new 5-HT1A receptor antagonist ligand, [3H]p-MPPF, 4-(2'-methoxy-)-phenyl-1-[2'-(N-2"-pyridyl)-p-fluorobenzamido] ethyl-piperazine, was prepared and characterized. It demonstrated high affinity and selectivity toward 5-HT1A receptors (Kd = 0.34 +/- 0.12 nM and Bmax = 145 +/- 35 fmol/mg protein in rat hippocampal membrane
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