M2389
N6-甲基-2′-脱氧腺苷
≥98% (TLC), powder
别名:
6mdA, N6-Me-dAdo, m6dA
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关于此项目
经验公式（希尔记法）:
C11H15N5O3
化学文摘社编号:
分子量:
265.27
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Solubility:
acetic acid: 49.00-51.00 mg/mL, clear, colorless
Storage temp.:
−20°C
产品名称
N6-甲基-2′-脱氧腺苷,
Quality Level
SMILES string
CNc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
InChI
1S/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1
InChI key
DYSDOYRQWBDGQQ-XLPZGREQSA-N
assay
≥98% (TLC)
form
powder
solubility
acetic acid: 49.00-51.00 mg/mL, clear, colorless
storage temp.
−20°C
Application
N6-甲基-2′-脱氧腺苷已用作标准品，结合超高效液相色谱法和三重四极杆质谱法（UHPLC-QQQ-MS/MS）来测定基因组DNA中的修饰碱基水平。它还用于研究其促进红系祖细胞增殖潜力。
Biochem/physiol Actions
N6-甲基-2′-脱氧腺苷（N6-Me-dAdo）是N6-甲基2′-脱氧腺苷3′,5′-二磷酸盐（N6MABP）的前体，后者是P2Y受体的一种竞争性和选择性抑制剂。它位于转录起始位点，在莱茵衣藻的增强基因表达中起作用。N6-Me-dAdo可增强内部转座因子，在果蝇的发育过程中处于较高水平。它在原核生物和原生生物中参与基因转录、DNA修复和复制的调节。与基因体互补的N6-Me-dAdo可能诱导人细胞的基因表达。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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