biological source
synthetic
Quality Level
sterility
non-sterile
assay
≥97% (HPLC)
form
lyophilized powder
composition
Peptide content, ≥70%
solubility
water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... PMCH(5367)
General description
Melanin Concentrating Hormone (MCH) is a 19 amino acid cyclic neuropeptide. It belongs to a group of orexigenic peptides. MCH is abundantly expressed in the hypothalamus.
Application
Melanin Concentrating Hormone has been used as a hepta-decapeptide to study its effects on the reproductive axis and follicular development in female Oreochromis mossambicus.
Biochem/physiol Actions
Melanin Concentrating Hormone (MCH) functions in regulating feeding and energy homeostasis. It also plays a role in modulating arousal, promoting motivated behaviors, sleep patterns, and reproductive physiology. MCH is involved in controlling rapid eye movement (REM) sleep in rats. It acts as a nonselective agonist of melanin-concentrating hormone receptors 1 and 2 (MCHR-1 and -2).
Other Notes
Lyophilized from 0.1% TFA in H2O
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M A Bednarek et al.
Biochemistry, 40(31), 9379-9386 (2001-08-02)
Human melanin-concentrating hormone (hMCH) is a potent but nonselective agonist at human melanin-concentrating hormone receptors 1 and 2 (hMCH-1R and hMCH-2R, respectively). To determine the structural features of this neuropeptide which are necessary for efficient binding to and activation of
The role of melanin concentrating hormone (MCH) in the central chemoreflex: a knockdown study by siRNA in the lateral hypothalamus in rats.
Li N
PLoS ONE (2014)
Patricia Lagos et al.
Brain research, 1265, 103-110 (2009-02-24)
Neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator are located in the lateral hypothalamus and incerto-hypothalamic area, and project diffusely throughout the central nervous system, including areas that participate in the generation and maintenance of the states of sleep
Genetic tests of biologic systems in affective disorders
E Hattori
Molecular Psychiatry (2005)
Melanin-concentrating hormone facilitates migration of preadipocytes.
Cook LB
Molecular and Cellular Endocrinology (2010)
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