M264
抗-谷氨酸受体NMDAR2A (NR2A) 兔抗
affinity isolated antibody, lyophilized powder
别名:
NR2A Antibody - Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit, Nr2A Antibody
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
分子量
antigen 180 kDa
种属反应性
rat, mouse, human
技术
immunohistochemistry: 1:1,000-1:2,000
immunoprecipitation (IP): 3 μL using 200 μg of rat brain
western blot: 1:1,000
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GRIN2A(2903)
mouse ... Grin2a(14811)
rat ... Grin2a(24409)
一般描述
N-甲基-D-天门冬胺酸（NMDA）受体复合物由NR1和NR2两类亚基组成。仅有一类NR1亚基尚未被鉴定而NR2A、NR2B、NR2C和NR2D这四种不同的NR2受体亚基均已被鉴定。尽管NR2亚基不会单独发挥功能，它们可以与NR1亚基结合以产生一系列不同的受体类型。一系列研究也表明由NR1和NR2亚基形成的受体复合物的功能属性主要是由复合物的NR2成分所决定的。NMDA受体是在突触后的并会在发育和成熟的中枢神经系统（CNS）的可塑性中起重要作用。NMDA受体的激动剂和拮抗剂已被提出可对多种CNS疾病具有治疗作用，包括中风、头部受伤、癫痫、疼痛和阿尔茨海默症。
抗-谷氨酸受体NMDAR2A（NR2A）多克隆兔抗可对NMDA受体的180 kDa NR2A亚基进行标记。该标记可被抗体与免疫原的预吸附所阻断。抗体不会与NR2B或NR2C亚基发生交叉反应。它与大鼠、小鼠和人体组织发生反应。
免疫原
NR2A的C末端部分（1253-1391位氨基酸）。
应用
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）
蛋白质免疫印迹分析（1篇论文）
抗-谷氨酸受体NMDAR2A（NR2A）多克隆兔抗可通过免疫细胞化学和免疫组织化学（IHC）技术，如免疫印迹和免疫沉淀对NMDA的180 kDa NR2A亚基进行检测和定量。它可作为探针用于确定180 kDa NR2A亚基在N-甲基-D-天门冬胺酸（NMDA）受体复合物的组装和功能中的存在和作用。
外形
从碳酸氢铵（5 mM）冻干
其他说明
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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NX210c is a disease-modifying dodecapeptide derived from the subcommissural organ-spondin that is under preclinical and clinical development for the treatment of neurological disorders. Here, using whole-cell patch-clamp recordings, we demonstrate that NX210c increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)- and GluN2A-containing N-methyl-D-aspartate
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Tonic inhibition mediated by extrasynaptic GABAARs regulates various brain functions. However, the mechanisms that regulate tonic inhibition remain largely unclear. Here, we report distinct actions of GluN2A- and GluN2B-NMDA receptors (NMDARs) on tonic inhibition in hippocampal neurons under basal and
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Molecular neurobiology, 56(10), 7136-7143 (2019-04-17)
A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity
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Frontiers in molecular neuroscience, 11, 226-226 (2018-08-25)
Down syndrome (DS), the main genetic cause of intellectual disability, is associated with an imbalance of excitatory/inhibitory neurotransmitter systems. The phenotypic assessment and pharmacotherapy interventions in DS murine models strongly pointed out glutamatergic neurotransmission alterations (specially affecting ionotropic glutamate receptors
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