M2787
2-十八烯酸单甘油酯
≥94% (TLC)
别名:
MG(0:0/18:1(9Z)/0:0), 2-油酸甘油单酯
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关于此项目
经验公式（希尔记法）:
C21H40O4
化学文摘社编号:
分子量:
356.54
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
InChI
1S/C21H40O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-20(18-22)19-23/h9-10,20,22-23H,2-8,11-19H2,1H3/b10-9-
SMILES string
[H]C(CO)(OC(CCCCCCC/C=C\CCCCCCCC)=O)CO
InChI key
UPWGQKDVAURUGE-KTKRTIGZSA-N
assay
≥94% (TLC)
form
liquid
functional group
ester
lipid type
neutral glycerides
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
2-单油精（2-油酰甘油）可用作GPR119激动剂，调节GLP-1的释放。2-单油精可用于区分和研究单酰基甘油脂肪酶的动力学。
Packaging
在氩气下包装。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Katrine B Hansen et al.
The Journal of clinical endocrinology and metabolism, 96(9), E1409-E1417 (2011-07-23)
Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1
Christopher J Fowler et al.
Biochemical pharmacology, 69(8), 1241-1245 (2005-03-30)
In the present study, the abilities of cyclooxygenated derivatives of 1-arachidonoylglycerol and related compounds to prevent the metabolism of [3H]2-oleoylglycerol and [3H]anandamide by cytosolic and membrane fractions, respectively, have been investigated. For each compound, nine concentrations (range 0.2-100 microM) were
S Vandevoorde et al.
British journal of pharmacology, 150(2), 186-191 (2006-12-05)
Two compounds, URB602 and URB754, have been reported in the literature to be selective inhibitors of monoacylglycerol lipase, although a recent study has questioned their ability to prevent 2-arachidonoyl hydrolysis by brain homogenates and cerebellar membranes. In the present study
Dong Cheng et al.
The Journal of biological chemistry, 283(44), 29802-29811 (2008-09-05)
Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of the four intestinal membrane bound acyltransferases implicated in dietary fat absorption. Recently, it was found that, in addition to acylating diacylglycerol (DAG), DGAT1 also possesses robust enzymatic activity for acylating monoacylglycerol
Unmesh Shah
Current opinion in drug discovery & development, 12(4), 519-532 (2009-06-30)
Type 2 diabetes (T2D) and associated obesity have reached epidemic proportions, and there is an increasing need for orally effective agents that regulate glucose homeostasis with a concurrent reduction in body weight. GPR119, a class-A (rhodopsin-like) G protein-coupled receptor, expressed
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