M2824
美普他酚 盐酸盐
别名:
3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-phenol hydrochloride, IL-22811 hydrochloride, WY-22811 hydrochloride
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关于此项目
经验公式（希尔记法）:
C15H23NO· HCl
CAS Number:
分子量:
269.81
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
质量水平
表单
powder
颜色
white to off-white
溶解性
H2O: >10 mg/mL
创始人
Wyeth
SMILES字符串
Cl.CCC1(CCCCN(C)C1)c2cccc(O)c2
InChI
1S/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H
InChI key
MPJUSISYVXABBH-UHFFFAOYSA-N
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相关类别
生化/生理作用
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic.
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.
特点和优势
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A Schnabel et al.
Der Anaesthesist, 60(11), 995-1001 (2011-09-16)
Epidural regional analgesia is still recommended as the gold standard for obstetric analgesia due to its high efficacy and less depressing effects to the central nervous system. However, if absolute or relative contraindications for a regional anesthetic technique are present
Xin-xing Ge et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 881-882, 126-130 (2011-12-30)
A rapid, simple and sensitive LC-MS/MS method was developed and validated for the determination of Bis(9)-(-)-Meptazinol (B9M) in rat plasma. Protein precipitation method was used for sample preparation, using five volumes of methanol as the precipitation agent. The analytes were
Qiong Xie et al.
Journal of molecular modeling, 12(4), 390-397 (2006-01-13)
Molecular docking has been performed to investigate the binding mode of (-)-meptazinol (MEP) with acetylcholinesterase (AChE) and to screen bis-meptazinol (bis-MEP) derivatives for preferable synthetic candidates virtually. A reliable and practical docking method for investigation of AChE ligands was established
A Galli et al.
The Journal of pharmacy and pharmacology, 43(5), 366-369 (1991-05-01)
The protective action of meptazinol against acute di-isopropyl fluorophosphate (DFP) intoxication has been evaluated in mice by measuring the effects on the DFP LD50 of the pretreatment of the animals with increasing doses of the drug. Meptazinol at the doses
Wei Li et al.
Acta pharmacologica Sinica, 26(3), 334-338 (2005-02-18)
To investigate the mechanism of action of a potent analgesic, (+/-)-meptazinol. The structures of meptazinol enantiomers were compared with opioid pharmacophore and tramadol. Neither enantiomer of meptazinol fitted any patterns among the opioid pharmacophore and tramadol, although they did share
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