M3152
甲氧基聚乙二醇琥珀酸酯N-羟基琥珀酰亚胺
~50%, mol wt ~5,000
别名:
单-甲基聚乙二醇琥珀酸酯N-琥珀酰亚胺酯, PEG-琥珀酰亚胺琥珀酸酯, 甲氧基聚乙二醇5000琥珀酸N-琥珀酰亚胺酯
分子量
~5,000
浓度
~50%
储存温度
−20°C
InChI
1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2
InChI key
OVPTZXRXNNJKSJ-UHFFFAOYSA-N
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应用
For protein modification. May improve solubility and extend biological lifetime.
其他说明
Shearwater Polymers 的产品
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H Matsuyama et al.
Biological & pharmaceutical bulletin, 16(2), 107-111 (1993-02-01)
Purified sphingomyelinase of Streptomyces A9107 (NRRL 15100) was modified with ss-PEG, methoxypolyethyleneglycol succinimidyl succinate, without loss of activity toward sphingomyelin in the mixed micelles with detergents such as sodium deoxycholate and Triton X-100 or toward a water-soluble, synthetic substrate, HNP
M S Hershfield et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(16), 7185-7189 (1991-08-15)
Modification by covalent attachment of polyethylene glycol (PEG) can reduce the immunogenicity and prolong the circulating life of proteins, but the utility of this approach for any protein is restricted by the number and distribution of PEG attachment sites (e.g.
Soluble Polymer-Enzyme Adducts.
Abuchowski, A. and Davis, F.F. et al.
Enzymes as Drugs (1981)
M A Croyle et al.
Journal of virology, 75(10), 4792-4801 (2001-04-20)
Most of the early gene therapy trials for cystic fibrosis have been with adenovirus vectors. First-generation viruses with E1a and E1b deleted are limited by transient expression of the transgene and substantial inflammatory responses. Gene transfer is also significantly curtailed
Georgi As Georgiev et al.
Colloids and surfaces. B, Biointerfaces, 59(2), 184-193 (2007-06-26)
Foam thin liquid films (TLF) and monolayers at the air-water interface formed by DMPC mixed with DMPE-bonded poly (ethylene glycol)s (DMPE-PEG(550), DMPE-PEG(2000) and DMPE-PEG(5000)) were obtained. The influence of both (i) PEG chain size (evaluated in terms of Mw) and
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