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M3935

Meloxicam sodium salt hydrate

Name: Meloxicam sodium salt hydrate
Brand: SIGMA

≥98% (HPLC), anti-inflammatory agent, powder

别名:

4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide sodium hydrate, Metacam sodium salt hydrate, Mobec sodium salt hydrate, UH-AC 62XX sodium salt hydrate

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₂N₃NaO₄S₂ · xH₂O

化学文摘社编号:

71125-39-8

分子量:

373.38 (anhydrous basis)

UNSPSC Code:

51111800

PubChem Substance ID:

24278802

NACRES:

NA.77

MDL number:

MFCD11046047

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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属性

产品名称

Meloxicam sodium salt hydrate, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

light yellow to dark yellow

solubility

DMSO: 5 mg/mL, clear

originator

Boehringer Ingelheim

storage temp.

room temp

SMILES string

O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O

InChI

1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1

InChI key

IZBZAOZGNNQKPJ-UHFFFAOYSA-M

Gene Information

human ... PTGS2(5743)

说明

Application

Meloxicam sodium salt hydrate has been used:

as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor
as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures
as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)
to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells

Biochem/physiol Actions

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution. Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain. Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor (NGF) in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro. It promotes apoptosis in hepatocellular carcinoma.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000479818

0000420368

0000361590

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Cyclooxygenase-2 enzyme inhibitors: place in therapy.

Noble SL, et al.

Am. Fam. Physician., 61(12), 3669-3676 (2000)

Safety of meloxicam to critically endangered Gyps vultures and other scavenging birds in India

Swarup DPRC, et al.

Animal Conservation, 10(2), 192-198 (2007)

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全球贸易项目编号

货号	GTIN
M3935-100MG	04061834052333