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M3935

Meloxicam sodium salt hydrate

Name: Meloxicam sodium salt hydrate
Brand: SIGMA

≥98% (HPLC), anti-inflammatory agent, powder

别名:

4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide sodium hydrate, Metacam sodium salt hydrate, Mobec sodium salt hydrate, UH-AC 62XX sodium salt hydrate

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₂N₃NaO₄S₂ · xH₂O

化学文摘社编号:

71125-39-8

分子量:

373.38 (anhydrous basis)

UNSPSC Code:

51111800

PubChem Substance ID:

24278802

NACRES:

NA.77

MDL number:

MFCD11046047

Assay:

≥98% (HPLC)

Form:

powder

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属性

产品名称

Meloxicam sodium salt hydrate, ≥98% (HPLC)

Quality Segment

200

assay

≥98% (HPLC)

form

powder

color

light yellow to dark yellow

solubility

DMSO: 5 mg/mL, clear

originator

Boehringer Ingelheim

storage temp.

room temp

SMILES string

O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O

InChI

1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1

InChI key

IZBZAOZGNNQKPJ-UHFFFAOYSA-M

Gene Information

human ... PTGS2(5743)

说明

Application

Meloxicam sodium salt hydrate has been used:

as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor
as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures
as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)
to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells

Biochem/physiol Actions

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution. Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain. Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor (NGF) in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro. It promotes apoptosis in hepatocellular carcinoma.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

GHS06

警示词

Danger

危险代码

H301,H315,H319,H335

预防性声明

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)