M4052
Anti-Matrix Metalloproteinase-13, Hinge Region antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-MMP-13
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000 using a whole cell extract from a stimulated human cell line
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MMP13(4322)
Immunogen
synthetic peptide corresponding to the hinge region of human matrix metalloproteinase-13 (collagenase-3).
Biochem/physiol Actions
By immunoblotting against the reduced protein, the antibody reacts with bands at 60 kDa (the latent pro-form), as well as the 48 kDa active form, and other intermediate activation forms. It also reacts with non-reduced MMP-13.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
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The inability to distinguish periapical cysts from granulomas before performing root canal treatment leads to uncertainty in treatment outcomes because cysts have lower healing rates. Searching for differential expression of molecules within cysts or granulomas could provide information with regard
G A Homandberg et al.
Osteoarthritis and cartilage, 14(8), 793-806 (2006-04-04)
To test the effectiveness of glucosamine (GluNH(2))-HCl, chondroitin sulfate (CS) and mixtures in protecting cartilage exposed to fibronectin fragments (Fn-fs), an exposure known to enhance catabolic cytokines and matrix metalloproteinases (MMPs). Pharmacologic formulations of GluNH(2) (FCHG49) and CS (TRH122) (Nutramax
Kohei Nishitani et al.
Journal of cellular biochemistry, 109(2), 425-433 (2009-12-10)
Prostaglandin E2 (PGE2) is one of pro-inflammatory mediators. PGE2 maintains the homeostasis of many organs including articular cartilage, and a previous report showed that continuous inhibition of PGE2 accelerates the progression of osteoarthritis (OA). While PGE2 inhibits matrix metalloprotease (MMP)
Mohammed El Mabrouk et al.
Biochimica et biophysica acta, 1773(3), 309-320 (2007-01-09)
Molecular mechanisms of oncostatin M (OSM)-stimulated cartilage extracellular matrix catabolism and signaling pathways were investigated in human arthritic chondrocytes. OSM, alone or with Interleukin-1 (IL-1beta), increased glycosaminoglycan release and induced ADAMTS-4 and MMP-13 protein expression in human cartilage explants. OSM
Sohel M Julovi et al.
Arthritis and rheumatism, 50(2), 516-525 (2004-02-12)
To investigate the mechanism of the inhibitory action of hyaluronan (HA) on interleukin-1beta (IL-1beta)-stimulated production of matrix metalloproteinases (MMPs) in human articular cartilage. IL-1beta was added to normal and osteoarthritic (OA) human articular cartilage in explant culture to stimulate MMP
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