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Merck
CN

M4786

Met-Gly-Met-Met

≥97%

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关于此项目

经验公式(希尔记法):
C17H32N4O5S3
化学文摘社编号:
分子量:
468.65
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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assay

≥97%

form

solid

InChI

1S/C17H32N4O5S3/c1-27-7-4-11(18)15(23)19-10-14(22)20-12(5-8-28-2)16(24)21-13(17(25)26)6-9-29-3/h11-13H,4-10,18H2,1-3H3,(H,19,23)(H,20,22)(H,21,24)(H,25,26)

SMILES string

CSCCC(N)C(=O)NCC(=O)NC(CCSC)C(=O)NC(CCSC)C(O)=O

InChI key

BOCWTHDHJPOLAY-UHFFFAOYSA-N

technique(s)

cell culture | mammalian: suitable

storage temp.

−20°C

Biochem/physiol Actions

Met-Gly-Met-Met is a peptide substrate.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Amino-terminal extension present in the methionine aminopeptidase type 1c of Mycobacterium tuberculosis is indispensible for its activity
Kanudia et al.
BMC Biochemistry, 12, online-online (2011)
Pavitra Kanudia et al.
BMC biochemistry, 12, 35-35 (2011-07-07)
Methionine aminopeptidase (MetAP) is a ubiquitous enzyme in both prokaryotes and eukaryotes, which catalyzes co-translational removal of N-terminal methionine from elongating polypeptide chains during protein synthesis. It specifically removes the terminal methionine in all organisms, if the penultimate residue is
Oswaldo Hernandez-Hernandez et al.
Journal of chromatography. A, 1428, 202-211 (2015-08-19)
This work explores the use of both hydrophilic interaction liquid chromatography (HILIC) and reverse phase liquid chromatography (RPLC) for the separation and subsequent characterization of bovine caseinomacropeptide (CMP) phosphopeptides and O-glycopeptides using a quadrupole-time-of-flight (QTOF) mass spectrometer with electrospray ionization.
Aline Marschner et al.
Biochimie, 115, 35-43 (2015-04-30)
Methionine aminopeptidases play a major role in posttranslational protein processing and are therefore promising targets for the discovery of novel therapeutical agents. We here describe the heterologous expression, purification, and characterization of recombinant Trypanosoma brucei methionine aminopeptidase, type 1 (TbMetAP1).

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