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Merck
CN

M4943

Anti-phospho-MEK4 (pSer257/pThr261) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.44
MDL number:
MFCD06798497
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3

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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, frog, mouse

technique(s)

western blot: 0.1-1.0 μg/mL using extracts prepared from GST-tagged fusion protein expressing MEK 4.

UniProt accession no.

P45985

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MAP2K4(6416)
mouse ... Map2k4(26398)

General description

Mitogen-Activated Protein Kinase Kinase 4 (MEK 4 or MKK4) is a 42 kDa member of a tyrosine/threonine protein kinase family that activates the c-Jun NH2-terminal kinases (JNK), which is part of the inflammation/stress signaling pathway. The mutation of the MEK 4 gene in some carcinomas indicates that it may also have a role as a tumor suppressor. Phosphorylation of MEK4 by MEKK1 on serine 257 and threonine 261 in the catalytic domain activates the protein and enables MEK 4 to phosphorylate JNK
This antibody specifically recognizes human MEK 4 double phosphorylated at serine 257 and threonine 261. Mouse and frog MEK 4 (100% homology) may cross react.

Immunogen

synthetic MEK4-derived phosphopeptide that is phosphorylated at serine 257 and threonine 261.

Application

Anti-phospho-MEK4 (Tyr397) antibody may be used for detection by immunoblotting at a working concentration of 0.1-1.0 μg/mL.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

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存储类别

10 - Combustible liquids

法规信息

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分析证书(COA)

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A Cuenda
The international journal of biochemistry & cell biology, 32(6), 581-587 (2000-04-28)
The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines. JNK is a member of the MAP kinase
R J Davis
Biochemical Society symposium, 64, 1-12 (1999-04-20)
The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAP kinases) is activated by exposure of cells to environmental stress and by the treatment of cells with cytokines. The mechanism of activation of JNK is mediated by dual phosphorylation
C Hagemann et al.
Cellular signalling, 13(12), 863-875 (2001-12-01)
MEK kinases (MEKKs) comprise a family of related serine-threonine protein kinases that regulate mitogen-activated protein kinase (MAPK) signalling pathways leading to c-Jun NH2-terminal kinase (JNK) and p38 activation, induced by cellular stress (e.g., UV and gamma irradiation, osmotic stress, heat

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全球贸易项目编号

货号GTIN
M4943-1VL04061823102087

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