M5177
Anti-Matrix Metalloproteinase-9, C-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-MMP-9
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
human
浓度
~1 mg/mL
技术
western blot: 1:1,000 using concentrated cell culture medium from a stimulated human cell line (M2928)
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MMP9(4318)
一般描述
Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent proteinase which is also known as 92kDa gelatinase-B. It is expressed by various cells like granulocytes and mononuclear cells. The gene encoding it is localized on human chromosome 20q11.2-q13.1 and has 13 exons.
免疫原
synthetic peptide corresponding to the C-terminal end of human matrix metalloproteinase-9 (gelatinase-B).
生化/生理作用
By immunoblotting against the reduced protein, the antibody reacts with bands at 92 kDa and 88 kDa (the pro-form and active form). The antibody performs best on reduced proteins, but will react with non-reduced MMP-9. When used on reduced samples from tissue culture media, the antibody also recognizes a band at 65 kDa, which may be removed by enriching the gelatinase on gelatin-agarose.
Matrix metalloproteinase-9 (MMP-9) has been studied as a biomarker of nervous tissue inflammation in multiple sclerosis (MS).
外形
Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Vishnu C Ramani et al.
Biochimica et biophysica acta, 1813(8), 1525-1531 (2011-05-28)
The gelatinases, matrix metalloproteinase (MMP)-9 and -2, are produced as latent, inactive enzymes that can be proteolytically activated by a number of proteases. In many normal and pathological conditions, where the expression of MMPs is deregulated, changes in the expression
Senem Maral et al.
Medicine, 94(16), e732-e732 (2015-04-24)
Chronic myeloproliferative disorders such as polycythemia vera (PV), essential thrombocytosis (ET), and idiopathic myelofibrosis arise from clonal proliferation of neoplastic stem cells in the bone marrow. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have potential to degrade
Xiaoli Zhang et al.
Medical science monitor : international medical journal of experimental and clinical research, 21, 1115-1123 (2015-04-22)
The role of matrix metalloproteinase 9 (MMP-9) polymorphisms in breast cancer risk remains unclear. The purpose of this study was to evaluate the association between MMP-9 variants and breast cancer susceptibility. Case-control studies were searched on electronic databases to retrieve
Tereza C Cardoso et al.
Diagnostic pathology, 5, 57-57 (2010-09-14)
Meningoencephalitis by Herpesvirus type 5 (BoHV-5) in cattle has some features that are similar to those of herpetic encephalitis in humans and other animal species. Human Herpesvirus 3 (commonly known as Varicella-zoster virus 1), herpes simplex viruses (HSV), and equid
Y Benesová et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 15(3), 316-322 (2009-01-21)
Matrix metalloproteinases are notable contributors to neuroinflammation and blood-brain barrier disruption in multiple sclerosis (MS). The goal of this study was to determine the serum levels of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2), and their tissue inhibitors (TIMP-1) and (TIMP-2)
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