生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
mouse
技术
indirect ELISA: suitable
neutralization: suitable
western blot: suitable
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Cxcl2(20310)
一般描述
Macrophage Inflammatory Protein-2 belongs to the C-X-C family of chemokines and acts as chemoattractant for neutrophils. MIP-2 was originally identified as heparin-binding protein secreted in response to endotoxin. This chemokine acts majorly to induce influx of neutrophils following infection by pneumococci, hypersensitive reaction to viral antigen and inflammation due to glomerular nephritis. Pulmonary introduction of LPS results in rapid increase in the levels of MIP-2 producing inflammation. Anti-Macrophage Inflammatory Protein-2 antibody is specific for mouse MIP-2.
免疫原
recombinant mouse MIP-2 expressed in E. coli.
应用
Anti-Macrophage Inflammatory Protein-2 antibody may be used for ELISA at a working antibody concentration of 0.5-1.0 μg/ml. For immunoblotting, antibody concentration of 0.1-0.2 μg/ml is recommended. The antibody is suitable for neutralization reactions.
生化/生理作用
The antibody shows <5% cross-reactivity with recombinant human GROα, recombinant human GROβ and recombinant human GROγ.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Terrence M Tumpey et al.
Journal of virology, 76(16), 8050-8057 (2002-07-23)
BALB/c mice sensitized to herpes simplex virus type 1 (HSV-1) develop a vigorous delayed-type hypersensitivity (DTH) response upon intradermal virus antigen challenge. Although CD4(+) T cells are a key mediator of this response, neutrophils are the most abundant cells at
A B Lentsch et al.
Hepatology (Baltimore, Md.), 27(4), 1172-1177 (1998-04-16)
Hepatic injury induced by ischemia and reperfusion is an important clinical problem after liver resection or transplantation. Neutrophils are known to mediate the organ injury, but the precise mechanisms leading to hepatic neutrophil recruitment are undefined. Two CXC chemokines, macrophage
John B Zamjahn et al.
American journal of physiology. Lung cellular and molecular physiology, 301(4), L568-L574 (2011-07-12)
Previously we showed that cytokine-induced neutrophil chemoattractant (CINC), but not macrophage inflammatory protein-2 (MIP-2), is detected in plasma after intratracheal challenge with LPS or the particular chemokines. To further understand the differences between CINC and MIP-2 flux from the lung
L Feng et al.
The Journal of clinical investigation, 95(3), 1009-1017 (1995-03-01)
The role of the chemokine, macrophage inflammatory protein-2 (MIP-2), during anti-glomerular basement membrane (GBM) antibody (Ab) glomerulonephritis (GN) was studied. Rat MIP-2 cDNA had been cloned previously. Recombinant rat MIP-2 (rMIP-2) from Escherichia coli exhibited neutrophil chemotactic activity and produced
S D Wolpe et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(2), 612-616 (1989-01-01)
In response to endotoxin, macrophages secrete a protein with a molecular mass of approximately 6000 Da and with an affinity for heparin. This protein, which we term "macrophage inflammatory protein 2," is a potent chemotactic agent for human polymorphonuclear leukocytes.
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