M5684
Anti-Matrix Metalloproteinase-19, Propeptide Region antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-MMP-19
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC (f), IP, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen 58 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MMP19(4327)
General description
Matrix metalloproteinase-19 (MMP19) is a zinc-dependent endopeptidase. It contains a signal sequence, a propeptide domain, a catalytic domain and a carboxy-terminal fragment. The gene encoding this protein is located on human chromosome 12q14.
Immunogen
synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-19 (RASI).
Biochem/physiol Actions
Matrix metalloproteinase-19 (MMP-19) may have a role in arthritis and takes part in the advancement of lung cancer.
Reacts with reduced and non-reduced MMP-19. Recognizes the pro-form of MMP-19. Binds the propeptide region, which is removed during activation. Can be used to distinguish between the pro-form and active forms of MMP-19.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4 containing 50% glycerol and 15 mM sodium azide.
Still not finding the right product?
试用我们的 产品选型工具 工具缩小选择范围
法规信息
新产品
此项目有
J O Stracke et al.
The Journal of biological chemistry, 275(20), 14809-14816 (2000-05-16)
We have recently cloned MMP-19, a novel matrix metalloproteinase, which, due to unique structural features, was proposed to represent the first member of a new MMP subfamily (Pendás, A. M., Knäuper, V. , Puente, X. S., Llano, E., Mattei, M.
Guoying Yu et al.
American journal of respiratory and critical care medicine, 190(7), 780-790 (2014-09-25)
Lung cancer is the leading cause of cancer death in both men and women in the United States and worldwide. Matrix metalloproteinases (MMPs) have been implicated in the development and progression of lung cancer, but their role in the molecular
J O Stracke et al.
FEBS letters, 478(1-2), 52-56 (2000-08-03)
Matrix metalloproteinase (MMP)-19 and MMP-20 (enamelysin) are two recently discovered members of the MMP family. These enzymes are involved in the degradation of the various components of the extracellular matrix (ECM) during development, haemostasis and pathological conditions. Whereas MMP-19 mRNA