M5818
Monoclonal Anti-hMps1 antibody produced in mouse
~2 mg/mL, clone N1, purified immunoglobulin, buffered aqueous solution
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Conjugate:
unconjugated
Clone:
N1, monoclonal
Application:
ARR, IHC (f), IP, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N1, monoclonal
form
buffered aqueous solution
species reactivity
human
should not react with
mouse
concentration
~2 mg/mL
technique(s)
immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, microarray: suitable, western blot: 0.5-1.0 μg/mL using HeLa total cell extract
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TTK(7272)
General description
Human Mps1 kinase (hMps1) is a cell-cycle controlled protein that functions maximally during the M phase. hMps1 is involved in several cellular processes such as spindle assembly checkpoint, cell cycle progression, centrosome duplication and mitotic arrest . Monoclonal Anti-hMps1 is specific for human hMps1 and does not recognize mouse hMps1 (approx. 97 kDa).
Immunogen
recombinant catalytically inactive hMps1 (D663A) protein.
Application
Monoclonal Anti-hMps1 is suitable for use in ELISA, microarray, immunoprecipitation, immunocytochemistry and immunohistochemistry (frozen sections). The product may also be used for western blot (0.5-1.0 μg/mL using HeLa total cell extract).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Song-Tao Liu et al.
Molecular biology of the cell, 14(4), 1638-1651 (2003-04-11)
We have determined that the previously identified dual-specificity protein kinase TTK is the human orthologue of the yeast MPS1 kinase. Yeast MPS1 (monopolar spindle) is required for spindle pole duplication and the spindle checkpoint. Consistent with the recently identified vertebrate
Guillaume Combes et al.
Current biology : CB, 28(6), 872-883 (2018-03-06)
Monopolar spindle 1 (Mps1) is a conserved apical kinase in the spindle assembly checkpoint (SAC) that ensures accurate segregation of chromosomes during mitosis. Mps1 undergoes extensive auto- and transphosphorylation, but the regulatory and functional consequences of these modifications remain unclear.
Volker M Stucke et al.
The EMBO journal, 21(7), 1723-1732 (2002-04-03)
Budding yeast Mps1p kinase has been implicated in both the duplication of microtubule-organizing centers and the spindle assembly checkpoint. Here we show that hMps1, the human homolog of yeast Mps1p, is a cell cycle-regulated kinase with maximal activity during M
Harold A Fisk et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(25), 14875-14880 (2003-12-06)
The mitotic spindle is essential for the maintenance of genetic stability, and in budding yeast its assembly and function depend on the Mps1 protein kinase. Mps1p is required for centrosome duplication and the spindle checkpoint. Several recent reports demonstrate that
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