M6315
Monoclonal Anti-Mismatch Repair Protein 2 antibody produced in mouse
~1 mg/mL, clone 2MSH01, tissue culture supernatant
别名:
Anti-MSH2
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关于此项目
Conjugate:
unconjugated
Clone:
2MSH01, monoclonal
Application:
IHC (p)
Citations:
3
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
2MSH01, monoclonal
mol wt
antigen 102 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MSH2(4436)
General description
Mismatch repair protein 2 (MSH2) possesses four domains and belongs to the mismatch repair (MMR) gene family. The gene encoding this protein is localized on human chromosome 2p21.
Immunogen
recombinant human mismatch repair protein 2 (MSH2).
Biochem/physiol Actions
Mismatch repair protein 2 (MSH2) plays a very important role in the DNA mismatch repair system. It repairs DNA damage which is induced by drugs. MSH2 dysfunction has been associated with nonpolyposis colorectal cancer (Lynch syndrome).
Physical form
Contains 15 mM sodium azide.
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存储类别
10 - Combustible liquids
法规信息
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
相关内容
Datasheet
H Chen et al.
Scandinavian journal of immunology, 81(2), 121-128 (2014-11-21)
γδT cells function as sentinels in early host responses to infections and malignancies. Previously, we found ectopically expressed human MutS homologue 2 (hMSH2), recognized by γδT cells, triggered a γδT cell-mediated cytolysis to tumor cells. However, the characteristics of hMSH2-specific
Jin Zhang et al.
Oncology reports, 32(5), 2199-2206 (2014-09-02)
The objective of the present study was to investigate the association between paclitaxel resistance, gene copy number, and gene expression in ovarian carcinoma, and to restore paclitaxel sensitivity in a paclitaxel-resistant ovarian carcinoma cell line by using hMSH2-targeting siRNA. Paclitaxel-resistant
Jen-Chung Ko et al.
Biochemical and biophysical research communications, 456(1), 506-512 (2014-12-10)
The anti-estrogen tamoxifen has been used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been identified. Human MutS homolog
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M6315-500UL | 04061836275945 |