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About This Item

MDL编号:
UNSPSC代码:
12352202
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生物来源

mouse

重组

expressed in E. coli

方案

≥97% (SDS-PAGE and N-terminal analysis)

表单

lyophilized powder

效能

40-100 ng/mL ED50/EC50

分子量

7.8 kDa

包装

pkg of 10 μg

储存条件

avoid repeated freeze/thaw cycles

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

UniProt登记号

储存温度

−20°C

基因信息

mouse ... Ccl4(20303)

一般描述

MIP-1α and MIP-1β (macrophage inflammatory protein) were originally co-purified from LPS stimulated mouse macrophages. Recombinant, mouse MIP-1β (rmMIP-1β) consists of 69 amino acids. MIP- 1β belongs to the chemokine β subfamily which is characterized by a C-C configuration at the first two cysteines. MIP-1β has endogenous pyrogenic activity when it is injected intravenously into rabbits. Although other cytokines, such as IL-1alpha, IL-1β and TNF have endogenous pyrogenic activity, the pyrogenic effects of these cytokines can be inhibited by cyclooxgenase blockers, while the pyrogenicity of MIP- 1β is unaffected by these agents. MIP-1β can synergize with the hematopoietic growth factors granulocyte macrophage CSF (GM-CSF) or macrophage CSF (M-CSF) to enhance colony formation.

生化/生理作用

MIP-1β has endogenous pyrogenic activity when it is injected intravenously into rabbits. MIP-1 can synergize with the hematopoietic growth factors granulocytemacrophage CSF (GM-CSF) or macrophage CSF (M-CSF) to enhance colony formation.

外形

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin

分析说明

The biological activity of MIP-1β was tested in culture by measuring its ability to inhibit hematopoietic stem cell proliferation in an in vitro colony assay.

历史批次信息供参考:

分析证书(COA)

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