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Merck
CN

M6762

Sigma-Aldrich

1-甲基-2-吡咯烷酮

别名:

N-甲基-2-吡咯烷酮, N-甲基吡咯烷酮, NMP

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关于此项目

经验公式（希尔记法）:
C5H9NO
化学文摘社编号:
872-50-4
分子量:
99.13
Beilstein:
106420
EC 号:
212-828-1
MDL编号:
MFCD00003193
UNSPSC代码:
12352005
PubChem化学物质编号:
329818036

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蒸汽密度

3.4 (vs air)

蒸汽压

0.29 mmHg ( 20 °C)
0.99 mmHg ( 40 °C)

自燃温度

518 °F

expl. lim.

9.5 %

折射率

n20/D 1.47 (lit.)

沸点

202 °C (lit.)
81-82 °C/10 mmHg (lit.)

mp

−24 °C (lit.)

溶解性

ethanol: miscible 0.1 mL/mL, clear, colorless (10%, v/v)
H2O: miscible
acetone: miscible
benzene: miscible
chloroform: miscible
diethyl ether: miscible
ethyl acetate: miscible

密度

1.028 g/mL at 25 °C (lit.)

储存温度

2-8°C

SMILES字符串

CN1CCCC1=O

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

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其他说明

This product has been replaced by M79603-Sigma-Aldrich | 1-Methyl-2-pyrrolidinone, ReagentPlus®, 99% | C5H9NO

法律信息

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(°F)

195.8 °F - Pensky-Martens closed cup

闪点(°C)

91 °C - Pensky-Martens closed cup

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
027K0134
017K0075
036K3695
036K3694
036K3693

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Chun-Wa Chung et al.
Journal of medicinal chemistry, 55(2), 576-586 (2011-12-06)
Bromodomain-containing proteins are key epigenetic regulators of gene transcription and readers of the histone code. However, the therapeutic benefits of modulating this target class are largely unexplored due to the lack of suitable chemical probes. This article describes the generation
Yun Ping Neo et al.
Journal of agricultural and food chemistry, 62(22), 5163-5172 (2014-05-16)
Effects of heat treatment on structure and physicochemical properties of zein (Ze) and gallic acid loaded zein (Ze-GA) electrospun fiber mats were investigated. The electrospun fiber mats displayed different surface and physicochemical properties after being heat-cured at 150 °C for
Ajit Dhananjay Jagtap et al.
European journal of medicinal chemistry, 85, 268-288 (2014-08-05)
A series of 6-acylureido derivatives containing a 3-(pyrrol-2-ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2-one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2-fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (54) was identified as a dual Aurora B/FLT3 inhibitor (IC50 = 0.4 nM and 0.5 nM, respectively).
Hsiao-Chun Wang et al.
European journal of medicinal chemistry, 84, 312-334 (2014-07-19)
Bioisosteric replacement of acylureido moiety in 6-acylureido-3-pyrrolylmethylidene-2-oxoindoline derivatives resulted in a series of malonamido derivatives with indolin-2-one scaffold (11-14). Further conformational restrictions of the malonamido moiety led to 2-oxo-1,2-dihydropyridine (21-25) or a 4-oxo-1,4-dihydropyridine derivatives (31-36). 4-Oxo-1,4-dihydropyridine derivatives were more potent
David S Hewings et al.
Journal of medicinal chemistry, 54(19), 6761-6770 (2011-08-20)
Histone-lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene transcription. Bromodomains bind acetylated lysines, acting as readers of the histone-acetylation code. Competitive inhibitors of this interaction have antiproliferative and anti-inflammatory properties. With 57 distinct
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Product Information Sheet - M6762

Product Information Sheet

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