M6792
Anti-Macrophage Inflammatory Protein-1β antibody produced in goat
IgG fraction of antiserum, lyophilized powder
别名:
Anti-MIP-1β
biological source
goat
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
neutralization: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CCL4(6351)
General description
The antibody will neutralize the biological activity of recombinant human, but not mouse MIP-1β. It will not neutralize the biological activity of recombinant human or mouse MIP-1α.
Immunogen
recombinant human MIP-1β, expressed in Sf 21 insect cells.
Biochem/physiol Actions
Macrophage inflammatory protein-1β (CCL4) belongs to a family of MIP-1 chemotactic cytokines (CC). The members of MIP-1 family have the ability to self-associate and form aggregates of high molecular weight. The self- aggregation is a reversible process and occurs in T cells, B cells and macrophages in response to inflammatory factors and bacterial endotoxins. This response results in inflammation and platelet degranulation.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Maurer et al.
The international journal of biochemistry & cell biology, 36(10), 1882-1886 (2004-06-19)
Macrophage inflammatory protein (MIP)-1alpha was identified 15 years ago as the first of now four members of the MIP-1 CC chemokine subfamily. These proteins termed CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL9/10 (MIP-1delta), and CCL15 (MIP-1gamma) according to the revised nomenclature for
M D Miller et al.
Critical reviews in immunology, 12(1-2), 17-46 (1992-01-01)
Studies conducted in many laboratories over the past several years have resulted in the identification and initial characterization of a large superfamily of structurally and functionally related inflammatory cytokines. This superfamily currently includes 14 distinct members: platelet factor 4, beta-thromboglobulin
L G Czaplewski et al.
The Journal of biological chemistry, 274(23), 16077-16084 (1999-05-29)
Human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation normal T cell expressed) self-associate to form high-molecular mass aggregates. To explore the biological significance of chemokine aggregation, nonaggregating variants were sought. The phenotypes of 105 hMIP-1alpha
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