生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~40 kDa
种属反应性
human, rat, mouse
包装
antibody small pack of 25 μL
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
~2 mg/mL
技术
western blot: 0.5-1 μg/mL using HEK-293T cells expressing human MO25 and PC12 cell lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CAB39(51719)
mouse ... Cab39(12283)
rat ... Cab39(301574)
一般描述
MO25 (mouse protein 25) is also termed calcium binding protein 39, CAB39 and CGI-66 is an Armadillo repeat domain scaffolding protein.
MO25 is a 40 kDa scaffolding protein that interacts with STRADα and LKB1 to regulate tumor suppression. MO25 activates LKB1 and also localizes LKB1 in the cytoplasm .
免疫原
synthetic peptide corresponding to amino acids 308-326 located near the C-terminus of human MO25. This sequence is identical in mouse, rat, dog, and bovine MO25.
应用
Anti-MO25 antibody is suitable for use in western blot (0.5-1 μg/mL using HEK-293T cells expressing human MO25 and PC12 cell lysates).
Anti-MO25 antibody produced in rabbit has been used in western blotting.
生化/生理作用
Anti-MO25 antibody is specific for MO25 in humans, rats and mice. In immunoblotting, staining of the MO25 band is specifically inhibited by the immunizing peptide.
MO25 (mouse protein 25) binds to Liver kinase B1 (LKB1) and STE20-related kinase adaptor (STRAD) and activates LKB1 and anchors it in the cell cytosol. LKB1 is a key regulator of AMP activated protein kinase (AMPK), which is a master regulator of cellular energy.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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此项目有
Analysis of the LKB1-STRAD-MO25 complex
Boudeau J, et al.
Journal of Cell Science, 117(26), 6365-6375 (2004)
LKB1-dependent signaling pathways
Alessi DR, et al.
Annual Review of Biochemistry, 75, 137-163 (2006)
A new mechanism for LKB1 activation
Lee SW and Lin HK
Molecular & Cellular Oncology, 5(3), e1035691-e1035691 (2018)
Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm
Miura S, et al.
American Journal of Physiology. Endocrinology and Metabolism, 305(2), E213-E229 (2013)
Marked phenotypic differences of endurance
Bruce CR, et al.
American Journal of Physiology. Endocrinology and Metabolism, 305, E213-E229 (2013)
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