M7070
Anti-MO25 兔抗
~2 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-CAB39, Anti-CGI-66, Anti-Calcium binding protein 39
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.44
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
human, rat, mouse
packaging
antibody small pack of 25 μL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~2 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using HEK-293T cells expressing human MO25 and PC12 cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CAB39(51719)
mouse ... Cab39(12283)
rat ... Cab39(301574)
General description
MO25 (mouse protein 25) is also termed calcium binding protein 39, CAB39 and CGI-66 is an Armadillo repeat domain scaffolding protein.
MO25 is a 40 kDa scaffolding protein that interacts with STRADα and LKB1 to regulate tumor suppression. MO25 activates LKB1 and also localizes LKB1 in the cytoplasm .
Immunogen
synthetic peptide corresponding to amino acids 308-326 located near the C-terminus of human MO25. This sequence is identical in mouse, rat, dog, and bovine MO25.
Application
Anti-MO25 antibody is suitable for use in western blot (0.5-1 μg/mL using HEK-293T cells expressing human MO25 and PC12 cell lysates).
Anti-MO25 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Anti-MO25 antibody is specific for MO25 in humans, rats and mice. In immunoblotting, staining of the MO25 band is specifically inhibited by the immunizing peptide.
MO25 (mouse protein 25) binds to Liver kinase B1 (LKB1) and STE20-related kinase adaptor (STRAD) and activates LKB1 and anchors it in the cell cytosol. LKB1 is a key regulator of AMP activated protein kinase (AMPK), which is a master regulator of cellular energy.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
法规信息
新产品
此项目有
Analysis of the LKB1-STRAD-MO25 complex
Boudeau J, et al.
Journal of Cell Science, 117(26), 6365-6375 (2004)
Marked phenotypic differences of endurance
Bruce CR, et al.
American Journal of Physiology. Endocrinology and Metabolism, 305, E213-E229 (2013)
Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm
Miura S, et al.
American Journal of Physiology. Endocrinology and Metabolism, 305(2), E213-E229 (2013)
A new mechanism for LKB1 activation
Lee SW and Lin HK
Molecular & Cellular Oncology, 5(3), e1035691-e1035691 (2018)
LKB1-dependent signaling pathways
Alessi DR, et al.
Annual Review of Biochemistry, 75, 137-163 (2006)
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持