M7192
Monoclonal Anti-Major Vault Protein antibody produced in mouse
250 μg/mL, clone MVP-37, tissue culture supernatant
别名:
Anti-LRP, Anti-Lung Resistance Protein, Anti-MVP
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
tissue culture supernatant
抗体产品类型
primary antibodies
克隆
MVP-37, monoclonal
分子量
antigen ~110 kDa
种属反应性
human
浓度
250 μg/mL
技术
immunocytochemistry: 1:20-1:50 using 4% paraformaldehyde-fixed cytospin preparations
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): 1:20-1:50
western blot: 1:50
同位素/亚型
IgG2b
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MVP(9961)
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一般描述
Major vault protein (MVP) is also called lung resistance protein (LRP). It forms the outer shell of vaults (ribonucleoprotein particles present in the cytoplasm).
免疫原
full length cloned human MVP/LRP.
生化/生理作用
Major vault protein (MVP) mediates responses of cells to stress and might play a role in multidrug resistance. It has been shown to be overexpressed in drug-resistant cancer cells.
Reacts with an internal epitope of MVP/LRP (p110).
外形
Supplied in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
法规信息
新产品
此项目有
Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells.
Tajitsu Y
International Journal of Molecular Medicine, 32(3), 703-708 (2013)
Daniela Lötsch et al.
Oncotarget, 4(11), 1904-1918 (2013-11-19)
Despite their ubiquitous expression and high conservation during evolution, precise cellular functions of vault ribonucleoparticles, mainly built of multiple major vault protein (MVP) copies, are still enigmatic. With regard to cancer, vaults were shown to be upregulated during drug resistance
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