M7192
Monoclonal Anti-Major Vault Protein antibody produced in mouse
250 μg/mL, clone MVP-37, tissue culture supernatant
别名:
Anti-LRP, Anti-Lung Resistance Protein, Anti-MVP
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关于此项目
Conjugate:
unconjugated
Clone:
MVP-37, monoclonal
Application:
ICC, IHC (f), IHC (p), WB
Citations:
2
biological source
mouse
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
MVP-37, monoclonal
mol wt
antigen ~110 kDa
species reactivity
human
concentration
250 μg/mL
technique(s)
immunocytochemistry: 1:20-1:50 using 4% paraformaldehyde-fixed cytospin preparations, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): 1:20-1:50, western blot: 1:50
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MVP(9961)
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General description
Major vault protein (MVP) is also called lung resistance protein (LRP). It forms the outer shell of vaults (ribonucleoprotein particles present in the cytoplasm).
Immunogen
full length cloned human MVP/LRP.
Biochem/physiol Actions
Major vault protein (MVP) mediates responses of cells to stress and might play a role in multidrug resistance. It has been shown to be overexpressed in drug-resistant cancer cells.
Reacts with an internal epitope of MVP/LRP (p110).
Physical form
Supplied in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
法规信息
新产品
此项目有
Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells.
Tajitsu Y
International Journal of Molecular Medicine, 32(3), 703-708 (2013)
Daniela Lötsch et al.
Oncotarget, 4(11), 1904-1918 (2013-11-19)
Despite their ubiquitous expression and high conservation during evolution, precise cellular functions of vault ribonucleoparticles, mainly built of multiple major vault protein (MVP) copies, are still enigmatic. With regard to cancer, vaults were shown to be upregulated during drug resistance
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