M7782
Antiflammin-1
≥97% (HPLC)
别名:
Anti-inflammatory peptide 1, Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser
SMILES string
CSCCC(N)C(=O)NC(CCC(N)=O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(O)=O
assay
≥97% (HPLC)
composition
Peptide content, ~70%
storage temp.
−20°C
Biochem/physiol Actions
Inhibits synthesis of platelet activating factor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Jennifer L Beal et al.
Biochemistry, 48(46), 11142-11148 (2009-10-21)
Electrophilic halogenating agents, including hypohalous acids and haloamines, oxidize free methionine and the N-terminal methionines of peptides and proteins (e.g., Met-1 of anti-inflammatory peptide 1 and ubiquitin) to produce dehydromethionine (a five-membered isothiazolidinium heterocycle). Amide derivatives of methionine are oxidized
Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions.
G Camussi et al.
Advances in experimental medicine and biology, 279, 161-172 (1990-01-01)
Inhibition of phospholipase A2 by uteroglobin and antiflammin peptides.
L Miele et al.
Advances in experimental medicine and biology, 279, 137-160 (1990-01-01)
N K Mize et al.
Experimental dermatology, 6(4), 181-185 (1997-08-01)
The potential of an anti-inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation
Jianzhong Han et al.
Cell biology international, 32(9), 1108-1115 (2008-06-11)
Antiflammin-1 (AF-1) is a synthetic nonapeptide with a similar sequence to the conserved sequence of CC10 secreted by lung Clara cells. Studies suggest that it is potent inhibitor of inflammation. We investigated the effects and possible mechanisms of AF-1 on
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