生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
TN-26, monoclonal
表单
buffered aqueous solution
种属反应性
mouse
技术
complement-mediated cytotoxicity assay: suitable
indirect immunofluorescence: suitable
同位素/亚型
IgM
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Thy1(21838)
一般描述
单克隆抗 Thy 1.1（小鼠 IgM 同种型）来源于小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生的杂交瘤。
胸腺细胞抗原 1 (Thy 1.1) 是一种糖基磷脂酰锚定蛋白。它属于免疫球蛋白超家族。Thy 1.1 在干细胞、T 细胞和神经元中表达。
免疫原
AKR/J (Thy 1.1) 小鼠的胸腺细胞。
应用
小鼠源抗Thy 1.1单克隆抗体可用于免疫淘选和免疫荧光。
生化/生理作用
研究表明，缺乏蛋白质胸腺细胞抗原 1 (Thy 1.1) 的小鼠成纤维细胞数量增加。这种成分可抑制真皮成纤维细胞的增殖并增强其凋亡，从而调节细胞生长。此过程通过调节β3整合素的作用实现。
识别Thy 1.1轴承细胞，与Thy 1.2轴承细胞的交叉反应小于5%。根据对AKR / J胸腺细胞的体外细胞毒性测定，滴度为1:20,000
外形
0.1 M磷酸盐缓冲液（pH 7.4，含有15 mM叠氮化钠）溶液
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yunsong Zhang et al.
Journal of molecular neuroscience : MN, 72(6), 1402-1412 (2022-05-17)
Cellular metabolism is essentially linked to tissue remodeling and organ regeneration. MOGS, a gene that encodes cellular metabolism-related protein mannosyl-oligosaccharide glucosidase, was found to be upregulated in nerve segments after peripheral nerve injury. Bioinformatic analyses identified upstream regulators of MOGS
Dongren Yang et al.
The Journal of cell biology, 168(4), 655-666 (2005-02-09)
Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer alpha2beta1gamma1) and Ln-8 (alpha4beta1gamma1). Loss of Ln-2 in humans and mice carrying alpha2-chain mutations prevents developing Schwann cells from fully defasciculating axons, resulting in partial amyelination. The principal pathogenic mechanism
Wendy A Neveu et al.
American journal of physiology. Cell physiology, 309(9), C616-C626 (2015-09-04)
Idiopathic pulmonary fibrosis is a progressive lung disease that increases in incidence with age. We identified a profibrotic lung phenotype in aging mice characterized by an increase in the number of fibroblasts lacking the expression of thymocyte differentiation antigen 1
Zhenghui Cheng et al.
BMC molecular and cell biology, 22(1), 21-21 (2021-04-09)
Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, SCs de-differentiate and reprogram to gain the
Yan Lu et al.
Neural regeneration research, 17(4), 911-919 (2021-09-03)
Peripheral nerve injury repair requires a certain degree of cooperation between axon regeneration and Wallerian degeneration. Therefore, investigating how axon regeneration and degeneration work together to repair peripheral nerve injury may uncover the molecular mechanisms and signal cascades underlying peripheral
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