产品名称
单克隆抗 Thy 1.1 小鼠抗, clone TN-26, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TN-26, monoclonal
form
buffered aqueous solution
species reactivity
mouse
technique(s)
complement-mediated cytotoxicity assay: suitable
indirect immunofluorescence: suitable
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Thy1(21838)
Application
小鼠源抗Thy 1.1单克隆抗体可用于免疫淘选和免疫荧光。
Biochem/physiol Actions
研究表明，缺乏蛋白质胸腺细胞抗原 1 (Thy 1.1) 的小鼠成纤维细胞数量增加。这种成分可抑制真皮成纤维细胞的增殖并增强其凋亡，从而调节细胞生长。此过程通过调节β3整合素的作用实现。
识别Thy 1.1轴承细胞，与Thy 1.2轴承细胞的交叉反应小于5%。根据对AKR / J胸腺细胞的体外细胞毒性测定，滴度为1:20,000
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
单克隆抗 Thy 1.1（小鼠 IgM 同种型）来源于小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生的杂交瘤。
胸腺细胞抗原 1 (Thy 1.1) 是一种糖基磷脂酰锚定蛋白。它属于免疫球蛋白超家族。Thy 1.1 在干细胞、T 细胞和神经元中表达。
Immunogen
AKR/J (Thy 1.1) 小鼠的胸腺细胞。
Physical form
0.1 M磷酸盐缓冲液（pH 7.4，含有15 mM叠氮化钠）溶液
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Zhenghui Cheng et al.
BMC molecular and cell biology, 22(1), 21-21 (2021-04-09)
Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, SCs de-differentiate and reprogram to gain the
Wendy A Neveu et al.
American journal of physiology. Cell physiology, 309(9), C616-C626 (2015-09-04)
Idiopathic pulmonary fibrosis is a progressive lung disease that increases in incidence with age. We identified a profibrotic lung phenotype in aging mice characterized by an increase in the number of fibroblasts lacking the expression of thymocyte differentiation antigen 1
Yannick Poitelon et al.
Methods in molecular biology (Clifton, N.J.), 1739, 233-253 (2018-03-17)
In the peripheral nervous system, axons dictate the differentiation state of Schwann cells. Most of this axonal influence on Schwann cells is due to juxtacrine interactions between axonal transmembrane molecules (e.g., the neuregulin growth factor) and receptors on the Schwann
Yunsong Zhang et al.
Journal of molecular neuroscience : MN, 72(6), 1402-1412 (2022-05-17)
Cellular metabolism is essentially linked to tissue remodeling and organ regeneration. MOGS, a gene that encodes cellular metabolism-related protein mannosyl-oligosaccharide glucosidase, was found to be upregulated in nerve segments after peripheral nerve injury. Bioinformatic analyses identified upstream regulators of MOGS
Dongren Yang et al.
The Journal of cell biology, 168(4), 655-666 (2005-02-09)
Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer alpha2beta1gamma1) and Ln-8 (alpha4beta1gamma1). Loss of Ln-2 in humans and mice carrying alpha2-chain mutations prevents developing Schwann cells from fully defasciculating axons, resulting in partial amyelination. The principal pathogenic mechanism
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