M8386
α,β-亚甲基腺苷 5′-二磷酸 钠盐
≥98% (HPLC), synthetic (organic), powder
别名:
AMP-CP
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关于此项目
经验公式（希尔记法）:
C11H17N5O9P2
化学文摘社编号:
分子量:
425.23
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
α,β-亚甲基腺苷 5′-二磷酸 钠盐, CD73 inhibitor
生物来源
synthetic (organic)
方案
≥98% (HPLC)
表单
powder
溶解性
water: 50 mg/mL, clear to slightly hazy, colorless
储存温度
−20°C
SMILES字符串
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)CP(O)(O)=O)C(O)C3O
InChI
1S/C11H17N5O9P2.Na.H/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21;;/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21);;
InChI key
HEBWZOPLDYDXPJ-UHFFFAOYSA-N
应用
αβ-亚甲基腺苷5′-二磷酸钠盐用作胞外核苷酸酶/CD73抑制剂，表征腺苷的产生模式 和作为 体外研究的抑制剂。
生化/生理作用
αβ-亚甲基腺苷5′-二磷酸（AMP-CP）是ADP类似物，具有抑制胞外核苷酸酶/CD73 的能力，通过CD73/胞外-5′-核苷酸酶，用于研究腺苷能信号调控。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion.
Charles C Caldwell et al.
Gastroenterology, 135(5), 1460-1462 (2008-10-14)
Camilla Mohlin et al.
Pharmacology, 84(4), 196-202 (2009-09-05)
Extracellular ATP may be metabolized to AMP and adenosine by the ectonucleotidases CD39 and CD73 and, in this study, we characterized the pathways for adenosine formation in human urinary tract epithelial cells. Bladder (RT4) and kidney (A498) epithelial cells were
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
Torres A
Oncotarget, 7, 67373-67386 (2016)
Gennady G Yegutkin et al.
European journal of immunology, 41(5), 1231-1241 (2011-04-07)
CD73/ecto-5'-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. The contribution of host CD73 to tumor growth and anti-tumor immunity has not been studied. Here, we show that under physiological conditions
Charles Dumontet et al.
European journal of medicinal chemistry, 157, 1051-1055 (2018-09-04)
The ecto-5'-nucleotidase CD73 has emerged as an important drug target in oncoimmunology as well as in other diseases. We describe new ADP analogues as CD73 inhibitors based on the replacement of the adenosine moiety, in the reference inhibitor APCP, by
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