M8386
α,β-亚甲基腺苷 5′-二磷酸 钠盐
≥98% (HPLC), synthetic (organic), powder
别名:
AMP-CP
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关于此项目
经验公式（希尔记法）:
C11H17N5O9P2
CAS Number:
分子量:
425.23
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
Product Name
α,β-亚甲基腺苷 5′-二磷酸 钠盐, CD73 inhibitor
生物来源
synthetic (organic)
质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
water: 50 mg/mL, clear to slightly hazy, colorless
储存温度
−20°C
SMILES字符串
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)CP(O)(O)=O)C(O)C3O
InChI
1S/C11H17N5O9P2.Na.H/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21;;/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21);;
InChI key
HEBWZOPLDYDXPJ-UHFFFAOYSA-N
相关类别
应用
αβ-亚甲基腺苷5′-二磷酸钠盐用作胞外核苷酸酶/CD73抑制剂，表征腺苷的产生模式 和作为 体外研究的抑制剂。
生化/生理作用
αβ-亚甲基腺苷5′-二磷酸（AMP-CP）是ADP类似物，具有抑制胞外核苷酸酶/CD73 的能力，通过CD73/胞外-5′-核苷酸酶，用于研究腺苷能信号调控。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion.
Charles C Caldwell et al.
Gastroenterology, 135(5), 1460-1462 (2008-10-14)
Eleni Priglinger et al.
Journal of extracellular vesicles, 10(12), e12156-e12156 (2021-10-21)
Interest in mesenchymal stem cell derived extracellular vesicles (MSC-EVs) as therapeutic agents has dramatically increased over the last decade. Current approaches to the characterization and quality control of EV-based therapeutics include particle tracking techniques, Western blotting, and advanced cytometry, but
Jussi Niemelä et al.
European journal of immunology, 38(10), 2718-2726 (2008-10-01)
IFN-beta treatment reduces the relapse rate in MS but its mechanism of action remains incompletely understood. Our aim was to clarify the beneficial effect of IFN-beta in the treatment of MS. We assessed the influence of IFN-beta treatment on (i)
Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration
Rampon C, et al.
Purinergic Signaling, 10(4), 595-602 (2014)
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
Torres A
Oncotarget, 7, 67373-67386 (2016)
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