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Merck
CN

M8442

Anti-Matrix Metalloproteinase-21, C-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-MMP-21

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关于此项目

UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

mouse, rat, human, Xenopus

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MMP21(118856)
mouse ... Mmp21(214766)
rat ... Mmp13(171052)

General description

Matrix metalloproteinase-21 (MMP-21) is a secreted protein expressed in fetal tissues, adult tissues and cancer cell lines. It is a 57kDa protein. The gene encoding it is localized on chromosome 10 and is made up of seven exons.

Immunogen

synthetic peptide corresponding to the carboxyterminal end of human matrix metalloproteinase 21.

Biochem/physiol Actions

By immunoblotting against the reduced protein, the antibody identifies bands at 70 kDa and 66 kDa.
Matrix metalloproteinase-21 (MMP-21) is involved in increasing the invasion capacity and metastasis property of tumors.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

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Katja Ahokas et al.
Gene, 301(1-2), 31-41 (2002-12-20)
We have characterized a novel human matrix metalloproteinase (MMP-21) from human placenta DNA complementary to RNA (cDNA). The 569 amino acid translation of the cDNA includes all the typical features of an MMP family member, namely a signal sequence, a
Tiina Skoog et al.
Experimental dermatology, 15(10), 775-783 (2006-09-21)
Matrix metalloproteinase (MMP)-21 and MMP-26 (matrilysin-2) are two recently cloned epithelial metalloproteases. Here we examined their expression in various benign skin disorders, in which macrophages and fibroblasts have been implicated as well as in cultures of these cells. Expression of
Tao Wu et al.
Medical oncology (Northwood, London, England), 30(1), 323-323 (2013-01-01)
Matrix metalloproteinase-21 (MMP-21) has been shown to enhance tumor invasion and metastasis ability in some solid tumors. In the present study, we investigated the expression of MMP-21 as well as its association with overall survival of gastric cancer patients. MMP-21

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