M8759
3-马来酰亚胺基苯甲酸 N -羟基琥珀酰亚胺酯
别名:
MBS
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关于此项目
经验公式（希尔记法）:
C15H10N2O6
化学文摘社编号:
分子量:
314.25
EC Number:
261-368-8
UNSPSC Code:
47101511
PubChem Substance ID:
Beilstein/REAXYS Number:
1505254
MDL number:
InChI key
LLXVXPPXELIDGQ-UHFFFAOYSA-N
InChI
1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2
SMILES string
O=C1CCC(N1OC(C2=CC=CC(N3C(C=CC3=O)=O)=C2)=O)=O
mp
175-177 °C (lit.)
solubility
ethyl acetate or DMF: ≤20 mg/mL (may require addition of solvent to coupling buffer to at least 5% to maintain solubility)
storage temp.
−20°C
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Application
对伯胺和巯基具有反应性的双异官能化交联剂。通常，初始反应在 pH 为 7.0 时，通过酰胺键偶联至含伯胺的分子，然后在相同 pH 通过硫醚偶联至含巯基的化合物。用于制备酶免疫交联剂和半抗原载体分子偶联物。
Other Notes
芳基马来酰亚胺比烷基马来酰亚胺连接基更不稳定。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
D A Barton et al.
Journal of microscopy, 237(1), 79-88 (2010-01-09)
Accurate preservation of microtubule and actin microfilament arrays is crucial for investigating their roles in plant cell development. Aldehyde fixatives such as paraformaldehyde or glutaraldehyde preserve cortical microtubule arrays but, unless actin microfilaments are stabilized with drugs such as m-maleimidobenzoyl
T Arata
Journal of biochemistry, 109(2), 335-340 (1991-02-01)
Polymerization of G-actin in the presence of salt and phalloidin was blocked by treatment of G-actin with m-maleimidobenzoic acid N-hydroxysuccinimide ester (MBS) (designated as m-actin). The actin dimer produced by chemical crosslinking of F-actin with N,N'-p-phenylenedimaleimide did not polymerize and
Tatsuya Maruhashi et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 38(7), 485-490 (2015-03-06)
The RhoA/Rho-associated kinase (ROCK) pathway has a key physiological role in the pathogenesis of atherosclerosis. Increased ROCK activity is associated with cardiovascular diseases. Endogenous nitric oxide (NO) has an anti-atherosclerotic effect, whereas the exogenous NO-mediated cardiovascular effect still remains controversial.
N Sattayasai et al.
Journal of interferon research, 11(1), 41-48 (1991-02-01)
Antibodies to three conserved regions of all human interferon (IFN)-alpha 1 subtypes were raised by immunizing rabbits with short synthetic peptides coupled to a carrier. These peptides correspond to amino acid residues 29-36, 31-36, 126-131, 139-151, and 142-151 of the
H H Keah et al.
The journal of peptide research : official journal of the American Peptide Society, 57(1), 1-10 (2001-02-13)
The synthesis of peptides containing 0, 1 and 2 cysteine residues related to the human sperm tail protein, tpx-1, is described. These synthetic peptides, following conjugation to keyhole limpet hemocyanin modified with maleimidobenzoic acid N-hydroxysuccinimide ester, were used as immunogens
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