M9190
Methyl 14(S),15(S)-epoxy-11(R,S)-hydroxy-(5Z,8Z,12E)-eicosatrienoate
≥95% (HPLC), hexane solution
质量水平
方案
≥95% (HPLC)
表单
hexane solution
官能团
ester
脂质类型
unsaturated FAs
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCCC1O[C@H]1\C=C\C(O)C\C=C/C\C=C/CCCC(=O)OC
InChI
1S/C21H34O4/c1-3-4-10-14-19-20(25-19)17-16-18(22)13-11-8-6-5-7-9-12-15-21(23)24-2/h5,7-8,11,16-20,22H,3-4,6,9-10,12-15H2,1-2H3/b7-5-,11-8-,17-16+/t18?,19-,20-/m0/s1
InChI key
MHXSCMMMTRMMBI-PUWVHZPJSA-N
应用
Methyl 14(S),15(S)-epoxy-11(R,S)-hydroxy-(5Z,8Z,12E)-eicosatrienoate may be used as a reference material in the analysis and identification of 15-lipoxygenase metabolites.
其他说明
15-Lipoxygenase product of arachidonic acid, formed by a similar biosynthesis as hepoxilins.
警示用语：
Danger
危险分类
Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3
靶器官
Central nervous system, Nervous system
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
-14.8 °F - closed cup
闪点(°C)
-26 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Nitin T Aggarwal et al.
Vascular pharmacology, 56(1-2), 106-112 (2011-12-27)
Endothelial 15-lipoxygenase-1 (15-LO-1) metabolites of arachidonic acid (AA), 11,12,15-trihydroxyeicosatrienoic acid (THETA) and 15-hydroxy-11,12-epoxyeicosatrienoic acid (HEETA) and nitric oxide (NO) mediate relaxations to acetylcholine (ACH). However, interactions between NO and the 15-LO-1 pathway have not been explored. Therefore, the effect of
S Bhattacharya et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 30(4), 185-199 (2009-09-16)
Enzymes involved in the oxidative metabolism of n-6 polyunsaturated fatty acids, like lipoxygenase (LOX) and cyclooxygenase (COX), are significant in the pathogenesis of colorectal cancer. Of these enzymes, 15-LOX-1 is expressed in colon. Aim of this article is to describe
Sasikumar J Soumya et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 61(7), 707-718 (2012-03-28)
15(S)-Hydroxyeicosatetraenoic acid [15(S)-HETE] and 15(S)-hydroperoxyeicosatetraenoic acid [15(S)-HPETE] are the products of arachidonic acid formed in the 15-lipoxygenase pathway. They have opposing effects on the inflammatory process. The present study was designed to examine the role of these metabolites on angiogenesis
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