Anti-Melanocortin 1 Receptor antibody produced in rabbit

Anti-Melanocortin 1 Receptor is produced in rabbit using as immunogen a synthetic peptide conjugated to KLH. The peptide corresponds to the third cytoplasmic loop of human Melanocortin 1 Receptor. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.

Anti-Melanocortin 1 Receptor specifically recognizes human melanocortin 1 receptor by immunohistochemistry in formalin-fixed, paraffin-embedded tissues. Not tested for other uses. The immunizing peptide has 88% homology with the mouse gene. Other species reactivity has not been confirmed. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.

synthetic peptide corresponding to the third cytoplasmic loop of human melanocortin 1 receptor. The immunizing peptide has 88% homology with the mouse gene.

Anti-Melanocortin 1 Receptor antibody produced in rabbit was used in immunoblotting for chondrocyte protein extracts at a dilution of 1:2000.

Melanocortin 1 receptor (MC1R) is a G-protein coupled receptor that regulates the proliferation and differentiation of melanocytes. The melanocortin hormones activate MC1R that in turn triggers ERK1/2 pathway that promotes the synthesis of eumelanin pigments. Overexpression of MC1R is reported in a majority of human melanomas and acts as a marker in these tumor.

Solution in phosphate buffered saline containing ≤0.1 % sodium azide.

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