M9318
Anti-Melanocortin 4 Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-MC4R
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IHC (p)
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunocytochemistry: 4 μg/mL using human brain, caudate, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4 μg/mL using human brain, caudate
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MC4R(4160)
mouse ... Mc4r(17202)
rat ... Mc4r(25635)
Immunogen
synthetic peptide corresponding to the N-terminal extracellular domain of human melanocortin 4 receptor. The immunizing peptide has 94% homology with the rat and mouse gene.
Biochem/physiol Actions
Melanocortin 4 receptor (MC4R) is an important regulator of food intake and body weight in mammals. It also regulates energy homeostasis in response to neuropeptides. Polymorphisms in MC4R gene or haploinsufficiency results in early onset obesity in humans also termed melanocortin obesity syndrome.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
R A H Adan et al.
British journal of pharmacology, 149(7), 815-827 (2006-10-18)
Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of MC4R agonists decreases food intake, whereas inhibition of MC receptor activity by
Andrew A Butler
Peptides, 27(2), 281-290 (2006-01-26)
The melanocortins, a family of peptides produced from the post-translational processing of pro-opiomelanocortin (POMC), regulate ingestive behavior and energy expenditure. Loss of function mutations of genes encoding POMC, or of either of two melanocortin receptors expressed in the central nervous
Brandon L Panaro et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7050-7055 (2013-04-10)
Haploinsufficiency of the melanocortin-4 receptor (MC4R) results in melanocortin obesity syndrome, the most common monogenic cause of severe early onset obesity in humans. The syndrome, which produces measurable hyperphagia, has focused attention on the role of MC4R in feeding behavior
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