M9568
Anti-Muscarinic Acetylcholine Receptor M3 antibody produced in rabbit
affinity isolated antibody
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关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
—
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
immunoblotting: 1:2,000 (using ECL on rat brain lysate.)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHRM3(1131)
mouse ... Chrm3(12671)
rat ... Chrm3(24260)
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General description
Muscarinic Acetylcholine Receptor M3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
Muscarinic acetylcholine receptor M3 possesses a vestibule which is a part of a hydrophilic channel having a orthosteric binding site.
Immunogen
Synthetic peptide from the third extracellular loop of rat m3 (Accession P08483).
Biochem/physiol Actions
Muscarinic acetylcholine receptor M3 functions as a protectant in myocardial ischemia. It also has roles in smooth muscle contraction and glandular secretion. The receptor has a specific affinity for the Gq/11 family of G proteins.
Muscarinic acetylcholine receptor m3.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Patricia C Borck et al.
Clinical and experimental pharmacology & physiology, 47(2), 286-293 (2019-10-21)
Here, we investigate the effects of exercise training on glucose- and cholinergic-induced insulin secretion in pancreatic islets from obese and lean rats. Male Wistar rats were treated with monosodium glutamate (MSG) for the first 5 days of life, while control (CON)
Andrew C Kruse et al.
Nature, 482(7386), 552-556 (2012-02-24)
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence
Zhenyu Pan et al.
PloS one, 7(3), e32571-e32571 (2012-03-08)
The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury. However, the role of miRNAs in M(3)-mAChR mediated cardioprotection remains unexplored. The
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