M9693
Anti-Muscarinic Acetylcholine Receptor M2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2 μg/mL using brain tissue, neurons
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHRM2(1129)
mouse ... Chrm2(243764)
rat ... Chrm2(81645)
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General description
Muscarinic acetylcholine receptor M2 is expressed in the heart and many other tissues. The gene encoding it is localized on human chromosome 7.
Immunogen
synthetic peptide corresponding to the third cytoplasmic loop of human muscarinic acetylcholine receptor M2, conjugated to KLH. The immunizing peptide has 100% homology with the mouse and rat gene.
Biochem/physiol Actions
Muscarinic acetylcholine receptor M2 plays an important role in regulating functions of the heart and processes like pain perception and cognition. It is regarded as a good model in G protein-coupled receptors (GPCR) pharmacological studies. This receptor has a function in airway remodeling and it enhances the proliferation of airway smooth muscle cells (ASM) which is induced by transforming growth factor-β (TGF-β).
Physical form
Solution in phosphate buffered saline, containing 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Shirley Y Hill et al.
Psychiatry research, 209(3), 504-511 (2013-06-12)
P300 amplitude in childhood predicts substance use disorders by young adulthood. Trajectories of visual P300 amplitude show an association between low amplitude P300 and familial risk for alcohol dependence (AD). Variation in the cholinergic muscarinic receptor gene (CHRM2) has previously
Yinglong Miao et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(27), 10982-10987 (2013-06-20)
G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear.
Andrew C Kruse et al.
Nature, 504(7478), 101-106 (2013-11-22)
Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known about the mechanism of their activation process, as only the β2 adrenergic receptor (β2AR) and rhodopsin have been crystallized in fully active conformations. Here
Tjitske A Oenema et al.
American journal of respiratory cell and molecular biology, 49(1), 18-27 (2013-03-02)
Transforming growth factor-β₁ (TGF-β₁) is a central mediator in tissue remodeling processes, including fibrosis and airway smooth muscle (ASM) hyperplasia, as observed in asthma. The mechanisms underlying this response, however, remain unclear because TGF-β₁ exerts only weak mitogenic effects on
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